about
Synthetic and biological studies of tubulin targeting c2-substituted 7-deazahypoxanthines derived from marine alkaloid rigidinsFluorophore Labeled Kinase Detects Ligands That Bind within the MAPK Insert of p38α KinaseNovel Cyclopropyl-Indole Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors.Novel indole based NNRTIs with improved potency against wild type and resistant HIV.Bioactivity-guided mapping and navigation of chemical space.Synthesis of structurally simplified analogues of pancratistatin: truncation of the cyclitol ring.Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis.Inhibition of hepatitis B virus replication in vivo using lipoplexes containing altritol-modified antiviral siRNAs.In search of a cytostatic agent derived from the alkaloid lycorine: synthesis and growth inhibitory properties of lycorine derivativesMetathesis in the synthesis of aromatic compounds.In search of a treatment for HIV--current therapies and the role of non-nucleoside reverse transcriptase inhibitors (NNRTIs).Stealth lipoplex decorated with triazole-tethered galactosyl moieties: a strong hepatotropic gene vector.C1,C2-ether derivatives of the Amaryllidaceae alkaloid lycorine: retention of activity of highly lipophilic analogues against cancer cells.Synthesis of novel triazole-linked mefloquine derivatives: biological evaluation against Plasmodium falciparum.The synthesis of 2- and 3-aryl indoles and 1,3,4,5-tetrahydropyrano[4,3-b]indoles and their antibacterial and antifungal activity.The synthesis of angularly fused polyaromatic compounds by using a light-assisted, base-mediated cyclization reaction.1-Benzyl-3,3-dichloro-1H-indol-2(3H)-one.Metathesis reactions for the synthesis of ring-fused carbazoles.Developing Pantetheinase-Resistant Pantothenamide Antibacterials: Structural Modification Impacts on PanK Interaction and Mode of Action.Overcoming compound fluorescence in the FLiK screening assay with red-shifted fluorophores.Structure-based design, synthesis and biological evaluation of N-pyrazole, N'-thiazole urea inhibitors of MAP kinase p38α.2-{[(4-Methylphenyl)sulfonyl]amino}phenyl 4-methylbenzenesulfonateBidirectional racemic synthesis of the biologically active quinone cardinalin 3Composites of polyvinyl alcohol and carbon (coils, undoped and nitrogen doped multiwalled carbon nanotubes) as ethanol, methanol and toluene vapor sensorsCorrection to CAN-Mediated Oxidations for the Synthesis of Xanthones and Related ProductsOvercoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801Aryl Substituted Benzimidazolones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase InhibitorsThe Phylum Bryozoa: From Biology to Biomedical Potential
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P50
description
investigador
@es
researcher
@en
name
Willem A. Van Otterlo
@en
van Otterlo WA
@nl
type
label
Willem A. Van Otterlo
@en
van Otterlo WA
@nl
altLabel
van Otterlo WA
@en
prefLabel
Willem A. Van Otterlo
@en
van Otterlo WA
@nl
P31
P496
0000-0002-3300-6463