about
TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2.ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting INS-1E β-cells against lipotoxicity by improving the ER antioxidative capacity.N-glycosylation-negative catalase: a useful tool for exploring the role of hydrogen peroxide in the endoplasmic reticulum.Influence of cytokines on Dmt1 iron transporter and ferritin expression in insulin-secreting cells.The H2O2-sensitive HyPer protein targeted to the endoplasmic reticulum as a mirror of the oxidizing thiol-disulfide milieu.Modulation of Bcl-2-related protein expression in pancreatic beta cells by pro-inflammatory cytokines and its dependence on the antioxidative defense status.Importance of mitochondrial superoxide dismutase expression in insulin-producing cells for the toxicity of reactive oxygen species and proinflammatory cytokines.Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines.Impact of scavenging hydrogen peroxide in the endoplasmic reticulum for β cell function.Peroxiredoxin 4 improves insulin biosynthesis and glucose-induced insulin secretion in insulin-secreting INS-1E cells.Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis.Overexpression of the antioxidant enzyme catalase does not interfere with the glucose responsiveness of insulin-secreting INS-1E cells and rat islets.Triiodothyronine (T3)-mediated toxicity and induction of apoptosis in insulin-producing INS-1 cells.Induction of the intrinsic apoptosis pathway in insulin-secreting cells is dependent on oxidative damage of mitochondria but independent of caspase-12 activationHydrogen peroxide permeability of cellular membranes in insulin-producing cellsHeat shock protein B1 is a key mediator of prolactin-induced beta-cell cytoprotection against oxidative stress
P50
Q36324419-03CD3E3C-F998-47D6-BB2D-6605E737B67BQ38656835-77B9960F-9921-455C-A591-AA54378E111BQ38929460-56E163A4-DE41-408B-B2A6-6C1FD0D3BDE0Q38992824-C93D78F0-C715-41A2-9C58-53F97513A13FQ39291440-819B77E5-C89E-49FD-8421-45D1AA695BCEQ39646528-2AC2F9A2-172F-4C94-8FF5-047CCA50C52AQ40403790-CD0590B6-6835-47EE-831F-0E0E0AEB7A47Q40522089-F4427972-30FB-4689-BE0E-AB24E5762F3FQ40800176-3D241D59-04E1-414B-B224-F995EC59B47FQ42915513-594F921F-72F5-4C6A-8198-2700D2E522A4Q43116152-2C295A9A-6800-4D61-B7EC-4278CD1985C6Q44069335-BDA962E3-A4EA-433A-AF93-02AC0DC81DCFQ53561517-AECEF40B-E63F-4A03-8D42-8F1B51F80DD4Q84588286-36C7A637-BF87-4286-AC4B-CF73FD57C147Q91042691-B0953508-B7C8-451F-ABB7-08C3C17EDE21Q91279444-110711A1-14B0-4628-9332-2672049348A6
P50
description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Stephan Lortz
@en
Stephan Lortz
@nl
type
label
Stephan Lortz
@en
Stephan Lortz
@nl
prefLabel
Stephan Lortz
@en
Stephan Lortz
@nl
P31
P496
0000-0002-3392-8978