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Naturally Occurring Isothiocyanates Exert Anticancer Effects by Inhibiting Deubiquitinating EnzymesSubstoichiometric hydroxynonenylation of a single protein recapitulates whole-cell-stimulated antioxidant responseThe Die Is Cast: Precision Electrophilic Modifications Contribute to Cellular Decision MakingT-REX on-demand redox targeting in live cells.Prion-like nanofibrils of small molecules (PriSM) selectively inhibit cancer cells by impeding cytoskeleton dynamicsCaffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2.Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamersUbiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling.On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry.Cladribine and Fludarabine Nucleotides Induce Distinct Hexamers Defining a Common Mode of Reversible RNR Inhibition.Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies.β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling.Privileged Electrophile Sensors: A Resource for Covalent Drug Development.Subcellular Redox Targeting: Bridging in Vitro and in Vivo Chemical Biology.Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry.Akt3 is a privileged first responder in isozyme-specific electrophile response.Inhibitor mediated protein degradation.Using supramolecular hydrogels to discover the interactions between proteins and molecular nanofibers of small molecules.Uncoupling of allosteric and oligomeric regulation in a functional hybrid enzyme constructed from Escherichia coli and human ribonucleotide reductase.Boc3Arg-Linked Ligands Induce Degradation by Localizing Target Proteins to the 20S Proteasome.Precision Electrophile Tagging in Caenorhabditis elegans.Cardiovascular Small Heat Shock Protein HSPB7 Is a Kinetically Privileged Reactive Electrophilic Species (RES) Sensor.Ube2V2 Is a Rosetta Stone Bridging Redox and Ubiquitin Codes, Coordinating DNA Damage Responses.Stereodivergent and regioselective synthesis of 3,4-cis- and 3,4-trans-pyrrolidinediols from alpha-amino acids.Proteomics and Beyond: Cell Decision-Making Shaped by Reactive ElectrophilesChemical Biology Gateways to Mapping Location, Association, and Pathway ResponsivityGetting the Message? Native Reactive Electrophiles Pass Two Out of Three Thresholds to be Bona Fide Signaling MediatorsDiarylcarbonates are a new class of deubiquitinating enzyme inhibitorGetting the Right Grip? How Understanding Electrophile Selectivity Profiles Could Illuminate Our Understanding of Redox SignalingBreaking the Fourth Wall: Modulating Quaternary Associations for Protein Regulation and Drug DiscoverySingle-Protein-Specific Redox Targeting in Live Mammalian Cells and C. elegansPost-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1Redox Signaling by Reactive Electrophiles and OxidantsNuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3Interrogating Precision Electrophile SignalingCorrection to Redox Signaling by Reactive Electrophiles and OxidantsGenie in a bottle: controlled release helps tame natural polypharmacology?
P50
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P50
description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Marcus J C Long
@en
Marcus J C Long
@nl
type
label
Marcus J C Long
@en
Marcus J C Long
@nl
prefLabel
Marcus J C Long
@en
Marcus J C Long
@nl
P31
P496
0000-0002-0343-9671