about
Human genetic disorders and knockout mice deficient in glycosaminoglycanIdentification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4)Functional validation of novel compound heterozygous variants in B3GAT3 resulting in severe osteopenia and fractures: expanding the disease phenotype.Identification of a novel chondroitin hydrolase in Caenorhabditis elegans.Development of a mouse monoclonal antibody against the chondroitin sulfate-protein linkage region derived from shark cartilage.Pathophysiological Significance of Dermatan Sulfate Proteoglycans Revealed by Human Genetic Disorders.Involvement of human natural killer-1 (HNK-1) sulfotransferase in the biosynthesis of the GlcUA(3-O-sulfate)-Gal-Gal-Xyl tetrasaccharide found in α-thrombomodulin from human urine.Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome.Defect in dermatan sulfate in urine of patients with Ehlers-Danlos syndrome caused by a CHST14/D4ST1 deficiency.Pivotal Role of Carbohydrate Sulfotransferase 15 in Fibrosis and Mucosal Healing in Mouse ColitisISCSM2011 chondroitin sulfate E-type structure at tumor cell surface is involved in experimental metastasis.Glycosaminoglycans are functional ligands for receptor for advanced glycation end-products in tumors.Highly sulfated hexasaccharide sequences isolated from chondroitin sulfate of shark fin cartilage: insights into the sugar sequences with bioactivities.Analysis of the structure and neuritogenic activity of chondroitin sulfate/dermatan sulfate hybrid chains from porcine fetal membranes.Molecular interactions between chondroitin-dermatan sulfate and growth factors/receptors/matrix proteins.Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factorDe novo mutations in SLC35A2 encoding a UDP-galactose transporter cause early-onset epileptic encephalopathy.Receptor for advanced glycation end products (RAGE) functions as receptor for specific sulfated glycosaminoglycans, and anti-RAGE antibody or sulfated glycosaminoglycans delivered in vivo inhibit pulmonary metastasis of tumor cells.Hyaluronidases Have Strong Hydrolytic Activity toward Chondroitin 4-Sulfate Comparable to that for Hyaluronan.Identification of biallelic EXTL3 mutations in a novel type of spondylo-epi-metaphyseal dysplasia.Mutations in Biosynthetic Enzymes for the Protein Linker Region of Chondroitin/Dermatan/Heparan Sulfate Cause Skeletal and Skin DysplasiasIdentification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence.Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus.The reduction of heparan sulphate in the glomerular basement membrane does not augment urinary albumin excretion.Vascular abnormalities in the placenta of Chst14-/- fetuses: implications in the pathophysiology of perinatal lethality of the murine model and vascular lesions in human CHST14/D4ST1 deficiency.Sulfation patterns of exogenous chondroitin sulfate affect chondrogenic differentiation of ATDC5 cells.Chondroitin Sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) Deficiency Results in a Mild Skeletal Dysplasia and Joint Laxity.Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica.Effects of sesamin on the biosynthesis of chondroitin sulfate proteoglycans in human articular chondrocytes in primary culture.Chondroitin sulfate protects vascular endothelial cells from toxicities of extracellular histones.Proteoglycans and glycosaminoglycans improve toughness of biocompatible double network hydrogels.Clinical and radiographic features of the autosomal recessive form of brachyolmia caused by PAPSS2 mutations.Spondyloepiphyseal dysplasia, Omani type: Further definition of the phenotypeSynthesis of the glycosaminoglycan-protein linkage tetraosyl peptide moieties of betaglycan, which serve as a hexosamine acceptor for enzymatic glycosyl transferA response to: loss of dermatan-4-sulfotransferase 1 (D4ST1/CHST14) function represents the first dermatan sulfate biosynthesis defect, "dermatan sulfate-deficient Adducted Thumb-Clubfoot Syndrome". Which name is appropriate, "Adducted Thumb-ClubfooIdentification of novel LFNG mutations in spondylocostal dysostosisStructural alteration of glycosaminoglycan side chains and spatial disorganization of collagen networks in the skin of patients with mcEDS-CHST14CSGALNACT1-congenital disorder of glycosylation: A mild skeletal dysplasia with advanced bone ageCompositional analysis of the glycosaminoglycan family in velvet antlers of Sika deer (Cervus nippon) at different growing stagesScreening of known disease genes in congenital scoliosis
P50
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P50
description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Shuji Mizumoto
@en
Shuji Mizumoto
@nl
type
label
Shuji Mizumoto
@en
Shuji Mizumoto
@nl
prefLabel
Shuji Mizumoto
@en
Shuji Mizumoto
@nl
P108
P31
P496
0000-0002-4641-1505