about
Evidence of a specific interaction between new synthetic antisepsis agents and CD14.Purified monomeric ligand.MD-2 complexes reveal molecular and structural requirements for activation and antagonism of TLR4 by Gram-negative bacterial endotoxins.NMR studies of hexaacylated endotoxin bound to wild-type and F126A mutant MD-2 and MD-2·TLR4 ectodomain complexes.Endotoxin{middle dot}albumin complexes transfer endotoxin monomers to MD-2 resulting in activation of TLR4Isolation of monomeric and dimeric secreted MD-2. Endotoxin.sCD14 and Toll-like receptor 4 ectodomain selectively react with the monomeric form of secreted MD-2.Radioiodination of an endotoxin·MD-2 complex generates a novel sensitive, high-affinity ligand for TLR4.Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations.Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin.Molecular basis of reduced potency of underacylated endotoxins.Transfer of monomeric endotoxin from MD-2 to CD14: characterization and functional consequences.Endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolase.Specific high affinity interactions of monomeric endotoxin.protein complexes with Toll-like receptor 4 ectodomain.Biochemical and functional characterization of membrane blebs purified from Neisseria meningitidis serogroup B.Regulation of interactions of endotoxin with host cells.An essential role for albumin in the interaction of endotoxin with lipopolysaccharide-binding protein and sCD14 and resultant cell activation.High-affinity caspase-4 binding to LPS presented as high molecular mass aggregates or in outer membrane vesicles.
P50
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P50
name
Athmane Teghanemt
@en
Athmane Teghanemt
@nl
type
label
Athmane Teghanemt
@en
Athmane Teghanemt
@nl
prefLabel
Athmane Teghanemt
@en
Athmane Teghanemt
@nl