about
P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microgliaThe role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseasesRapid flow cytometric measurement of protein inclusions and nuclear trafficking.Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusionsP2X7 receptor antagonism in amyotrophic lateral sclerosis.Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis.Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell.Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanismsP2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice.Extracellular chaperones and proteostasis.Protein aggregates stimulate macropinocytosis facilitating their propagationExtracellular wildtype and mutant SOD1 induces ER-Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells.Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype.The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis.Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles.Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity.The heat shock response in neurons and astroglia and its role in neurodegenerative diseases.Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex.Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.Dysregulation of microRNA biogenesis machinery and microRNA/RNA ratio in skeletal muscle of amyotrophic lateral sclerosis mice.Evaluation of Skin Fibroblasts from Amyotrophic Lateral Sclerosis Patients for the Rapid Study of Pathological Features.Flow cytometric measurement of the cellular propagation of TDP-43 aggregation.Longitudinal assessment of metal concentrations and copper isotope ratios in the G93A SOD1 mouse model of amyotrophic lateral sclerosis.Addition of exogenous SOD1 aggregates causes TDP-43 mislocalisation and aggregation.Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis: A Study of Humans and a Transgenic Mouse Model.The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neuronsSOD1A4Vaggregation alters ubiquitin homeostasis in a cell model of ALSDynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosisAssessment of metal concentrations in the SOD1G93A mouse model of amyotrophic lateral sclerosis and its potential role in muscular denervation, with particular focus on muscle tissueUsing Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral SclerosisThe P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A miceThe microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteinsPrion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral SclerosisStrategies to promote the maturation of ALS-associated SOD1 mutants: small molecules return to the foldTrajectory Taken by Dimeric Cu/Zn Superoxide Dismutase through the Protein Unfolding and Dissociation Landscape Is Modulated by Salt Bridge FormationThe pivotal role of Ubiquitin-activating enzyme E1 (UBA1) in neuronal health and neurodegenerationNovel behavioural characteristics of the superoxide dismutase 1 G93A (SOD1G93A ) mouse model of amyotrophic lateral sclerosis include sex-dependent phenotypesThe Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron DifferentiationThe metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS
P50
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P50
description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Justin J Yerbury
@en
Justin J Yerbury
@nl
type
label
Justin J Yerbury
@en
Justin J Yerbury
@nl
prefLabel
Justin J Yerbury
@en
Justin J Yerbury
@nl
P31
P496
0000-0003-2528-7039