about
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitorsDiscovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylaseApplication of fundamental organometallic chemistry to the development of a gold-catalyzed synthesis of sulfinate derivatives.One-pot palladium-catalyzed synthesis of sulfonyl fluorides from aryl bromides.Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic TreatmentSpirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure.Discovery tactics to mitigate toxicity risks due to reactive metabolite formation with 2-(2-hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3h)-one derivatives, potent calcium-sensing receptor antagonists and clinical candidate(s) for the tDiscovery of a Novel Small-Molecule Modulator of C-X-C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis.Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems.Synthesis of spiropiperidine lactam acetyl-CoA carboxylase inhibitors.2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety.Cyclic Alkenylsulfonyl Fluorides: Palladium-Catalyzed Synthesis and Functionalization of Compact Multifunctional ReagentsSynthesis of 2-Arylpiperidines via Pd-Catalyzed Arylation of Aza-Achmatowicz Rearrangement Products with Arylboronic Acids
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description
investigador
@es
researcher
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name
Scott W Bagley
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type
label
Scott W Bagley
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prefLabel
Scott W Bagley
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P31
P496
0000-0002-7365-7332