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Age-related changes of leptin and leptin receptor variants in healthy elderly and long-lived adults.Long-term Monocyte Dysfunction after Sepsis in Humanized Mice Is Related to Persisted Activation of Macrophage-Colony Stimulation Factor (M-CSF) and Demethylation of PU.1, and It Can Be Reversed by Blocking M-CSF In Vitro or by Transplanting Naïve ADecreased expression and the Lys751Gln polymorphism of the XPD gene are associated with extreme longevity.SIRT1 and SIRT7 expression in adipose tissues of obese and normal-weight individuals is regulated by microRNAs but not by methylation status.miR-34a and miR-9 are overexpressed and SIRT genes are downregulated in peripheral blood mononuclear cells of aging humans.Acquired immunological imbalance after surgery with cardiopulmonary bypass due to epigenetic over-activation of PU.1/M-CSF.Aging is accompanied by a progressive decrease of expression of the WRN gene in human blood mononuclear cellsFunctional polymorphisms of the leptin and leptin receptor genes are associated with longevity and with the risk of myocardial infarction and of type 2 diabetes mellitus
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description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Jacek Polosak
@en
Jacek Polosak
@nl
type
label
Jacek Polosak
@en
Jacek Polosak
@nl
prefLabel
Jacek Polosak
@en
Jacek Polosak
@nl
P108
P31
P496
0000-0002-0033-2043