about
SCF(FBXW7α) modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stabilityBreast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3β dependent mechanism.βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy.Both p62/SQSTM1-HDAC6-dependent autophagy and the aggresome pathway mediate CDK1 degradation in human breast cancerLoss of FBXW7 and accumulation of MCL1 and PLK1 promote paclitaxel resistance in breast cancerG1/S phase progression is regulated by PLK1 degradation through the CDK1/βTrCP axis.A single mutation in Securin induces chromosomal instability and enhances cell invasionp53 and FBXW7: Sometimes Two Guardians Are Worse than One
P50
Q34100969-04156408-22CA-4C9C-804A-CD6191B67D03Q35569092-7DF5E996-9416-4155-81A1-6847EDE51EB3Q38963551-954259D0-5731-42E4-B9F3-DDC0C58C1AEFQ41564995-51A8B9D7-C9B5-4746-B7CC-A51C72FC23CAQ42274998-B46B0FE5-1F1B-4EF4-A73C-7B961D7F99ABQ50762663-05D1BEB2-1060-4D3E-9FCB-367D02FC0B17Q61700538-423A0A00-2E51-4CF5-8339-2623625B8025Q92121261-65E24B6B-6ECA-438D-9A94-48EA9DEBD550
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description
researcher
@en
name
Servando Giráldez
@en
type
label
Servando Giráldez
@en
prefLabel
Servando Giráldez
@en
P31
P496
0000-0001-9543-9347