The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particlesThe inhibition of assembly of HIV-1 virus-like particles by 3-O-(3',3'-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domain.The maturation inhibitor bevirimat (PA-457) can be active in patients carrying HIV type-1 non-B subtypes and recombinants.Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1 maturation inhibitor bevirimatBevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection.Impact of human immunodeficiency virus type 1 resistance to protease inhibitors on evolution of resistance to the maturation inhibitor bevirimat (PA-457)Protease-Mediated Maturation of HIV: Inhibitors of Protease and the Maturation ProcessAnti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids.Can the further clinical development of bevirimat be justified?Determinants of activity of the HIV-1 maturation inhibitor PA-457.
P921
Q21245046-02CF386B-AEFF-417E-B17A-B9FB6B7A1CF1Q30440445-AEBF81BE-9DDA-4401-ABB3-9EF399E52365Q33405849-8FD72E41-7989-4BDA-A35E-3C1A5C355BD6Q33864444-F3F4071B-162B-404B-9938-46AC6F4032D2Q34885660-3032777D-55F7-4FFC-911A-A541C0ADA8B2Q37192174-F7221E51-2F5C-4856-9D07-2A4FA61320FFQ41844750-78E61AEB-EFF2-4DFB-968B-ED19F60B1A87Q42285617-9F518119-92F7-45A2-9949-6293B81E2C85Q43162448-EA9585E5-5C95-4FE9-B821-D5C5EED7722EQ45173552-F8880F3D-B06F-4616-BEBE-E1D77E285546
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
Bevirimat
@de
Bevirimat
@fr
Bevirimat
@nl
Bevirimat
@sh
Bevirimat
@sr
Bevirimat
@vi
bevirimat
@en
type
label
Bevirimat
@de
Bevirimat
@fr
Bevirimat
@nl
Bevirimat
@sh
Bevirimat
@sr
Bevirimat
@vi
bevirimat
@en
altLabel
3-O-(3',3'-dimethylsuccinyl) betulinic acid
@en
BVM
@en
Bevirimat
@en
PA-457
@en
YK-FH312
@en
prefLabel
Bevirimat
@de
Bevirimat
@fr
Bevirimat
@nl
Bevirimat
@sh
Bevirimat
@sr
Bevirimat
@vi
bevirimat
@en
P592
P6366
P661
P662
P683
P117
P1579
P2017
CC(=C)[C@@H]1CC[C@]2([C@H]1[C@ ...... )OC(=O)CC(C)(C)C(=O)O)C)C(=O)O
P2065
P2067
P2275
bevirimat
@en
P231
174022-42-5
P232
P233
CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)OC(=O)CC(C)(C)C(=O)O)C)C(=O)O
P234
1S/C36H56O6/c1-21(2)22-12-17-3 ...... ,26-,28+,33-,34+,35+,36-/m0/s1
P235
YJEJKUQEXFSVCJ-WRFMNRASSA-N
P2566
100.125.475
P274
P3117
DTXSID20169749
P592
CHEMBL404519
P6366
2776275779