about
An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling.Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues.A structural insight into the P1S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases.Controlling the Helix Handedness of ααβ-Peptide Foldamers through Sequence Shifting.Identification of methionine aminopeptidase 2 as a molecular target of the organoselenium drug ebselen and its derivatives/analogues: Synthesis, inhibitory activity and molecular modeling study.Estimating kinetic constants in the Michaelis-Menten model from one enzymatic assay using Approximate Bayesian Computation
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Q34468476-DFD9BA55-7F1E-4FB6-9117-7E5412203C54Q35090932-9F5807E3-4A64-4EB5-A259-DB98B988A6BEQ36070656-821984B7-F34D-4F7C-9432-342B223C71E9Q36902177-C5479A0F-E5A2-4AA1-BC53-F71F701981E0Q48359838-5D2A7A68-3464-4BAB-8F1F-0B6F3ADF3409Q51443668-2752ABBD-D010-41FF-9BDB-B151E870136FQ91702077-6C0FFE6F-4FB1-4229-9E07-085795969E92
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description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Ewelina Węglarz-Tomczak
@en
Ewelina Węglarz-Tomczak
@nl
type
label
Ewelina Węglarz-Tomczak
@en
Ewelina Węglarz-Tomczak
@nl
prefLabel
Ewelina Węglarz-Tomczak
@en
Ewelina Węglarz-Tomczak
@nl
P31
P496
0000-0001-8080-2801