about
The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors.Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils.Replication stress is a potent driver of functional decline in ageing haematopoietic stem cellsReplication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem CellsChronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewalTranscription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation.Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells.Resilient and resourceful: genome maintenance strategies in hematopoietic stem cells.Surviving change: the metabolic journey of hematopoietic stem cells.Pro-inflammatory cytokines: emerging players regulating HSC function in normal and diseased hematopoiesis.Normal and leukemic stem cell niches: insights and therapeutic opportunities.Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing.Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.FOXO3A directs a protective autophagy program in haematopoietic stem cells.Autophagy maintains the metabolism and function of young and old stem cells.Born to survive: autophagy in hematopoietic stem cell maintenance.Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions.Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche.Initially disadvantaged, TEL-AML1 cells expand and initiate leukemia in response to irradiation and cooperating mutations.Linking HSCs to their youth.Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging.Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemiaLosing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic TransformationDeregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemiaTNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid RegenerationDysregulated haematopoietic stem cell behaviour in myeloid leukaemogenesis
P50
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description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Emmanuelle Passegué
@en
Emmanuelle Passegué
@nl
type
label
Emmanuelle Passegué
@en
Emmanuelle Passegué
@nl
prefLabel
Emmanuelle Passegué
@en
Emmanuelle Passegué
@nl
P108
P31
P496
0000-0002-3516-297X