about
Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivoThe aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species.Autoregulated paracellular clearance of amyloid-β across the blood-brain barrierC-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death.Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity.APP homodimers transduce an amyloid-β-mediated increase in release probability at excitatory synapses.Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies.
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Q34031193-DA0D1691-525B-4D12-9130-9A3BBF45AF9AQ35160799-2E7A0DCA-86D6-46F6-9393-9CDB718903C9Q36119212-62CA5368-15E6-4701-8FA7-A18114490D66Q36174787-6C1CD0FF-5325-42BD-B67F-99AEFEF065BEQ38847942-72574F36-55D7-4094-A6BD-6CBB1BEB2454Q41903311-1FED45A2-B045-464C-A5A8-ADE470B26161Q46616848-A05C22E9-7FCF-4BE5-BF9E-5AC4B0534F82Q53352144-802EEAD3-3E27-4595-BB9A-8320ED52B580
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description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Tiernan T O'Malley
@en
Tiernan T O'Malley
@nl
type
label
Tiernan T O'Malley
@en
Tiernan T O'Malley
@nl
prefLabel
Tiernan T O'Malley
@en
Tiernan T O'Malley
@nl
P31
P496
0000-0002-3538-0731