about
The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domainEukaryotic translation-initiation factor eIF2beta binds to protein kinase CK2: effects on CK2alpha activityThe replacement of ATP by the competitive inhibitor emodin induces conformational modifications in the catalytic site of protein kinase CK2The crystal structure of the complex of Zea mays alpha subunit with a fragment of human beta subunit provides the clue to the architecture of protein kinase CK2 holoenzymeStructural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazoleInhibition of protein kinase CK2 by anthraquinone-related compounds. A structural insightBiochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA)The ATP-binding site of protein kinase CK2 holds a positive electrostatic area and conserved water moleculesQuinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2ATP site-directed inhibitors of protein kinase CK2: an updateStructural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1AUnprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancerInhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insightCell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potentialSer/Thr phosphorylation of hematopoietic specific protein 1 (HS1): implication of protein kinase CK2Physical dissection of the structural elements responsible for regulatory properties and intersubunit interactions of protein kinase CK2 beta-subunitThe protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaksHematopoietic lineage cell specific protein 1 associates with and down-regulates protein kinase CK2.Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity.Inhibition of protein kinase CK2 by condensed polyphenolic derivatives. An in vitro and in vivo study.Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity.The selectivity of inhibitors of protein kinase CK2: an update.CK2: a protein kinase in need of control.The carboxy-terminal domain of Grp94 binds to protein kinase CK2 alpha but not to CK2 holoenzyme.Cystic fibrosis transmembrane regulator fragments with the Phe508 deletion exert a dual allosteric control over the master kinase CK2.Toward the rational design of protein kinase casein kinase-2 inhibitors.New potential peptide therapeutics perturbing CK1δ/α-tubulin interaction.The Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation.Features and potentials of ATP-site directed CK2 inhibitors.Protein kinase CK2 as a druggable target.Characterization of the oligomeric states of the CK2 α2β2 holoenzyme in solution.A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression.The lysine-specific demethylase 1 is a novel substrate of protein kinase CK2.Programmed cell death protein 5 (PDCD5) is phosphorylated by CK2 in vitro and in 293T cells.Extraordinary pleiotropy of protein kinase CK2 revealed by weblogo phosphoproteome analysis.Protein kinase CK2 catalyzes tyrosine phosphorylation in mammalian cells.Development and exploitation of CK2 inhibitors.Protein kinase CK2 phosphorylates and upregulates Akt/PKB.Modulation of protein kinase CK2 activity by fragments of CFTR encompassing F508 may reflect functional links with cystic fibrosis pathogenesisBovine prion protein as a modulator of protein kinase CK2
P50
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P50
description
biochemist in Italy
@en
name
Stefania Sarno
@en
type
label
Stefania Sarno
@en
altLabel
S. Sarno
@en
prefLabel
Stefania Sarno
@en
P1153
7004936830
P1960
b0CUXboAAAAJ
P2038
Stefania_Sarno