about
SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides.Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016).Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies.Synthesis, antimicrobial evaluation and molecular modeling of 5-hydroxyisoquinolinium salt series; the effect of the hydroxyl moiety.Rational Design of a New Class of Toll-Like Receptor 4 (TLR4) Tryptamine Related Agonists by Means of the Structure- and Ligand-Based Virtual Screening for Vaccine Adjuvant Discovery.In vitro and in silico evaluation of non-quaternary reactivators of AChE as antidotes of organophosphorus poisoning - a new hope or a blind alley?Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro.Profiling donepezil template into multipotent hybrids with antioxidant properties.Pyridinium oximes with ortho-positioned chlorine moiety exhibit improved physicochemical properties and efficient reactivation of human acetylcholinesterase inhibited by several nerve agentsNovel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking StudyButyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximesOxime K203: a drug candidate for the treatment of tabun intoxicationA 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxicationHighly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicityDonepezil Derivatives Targeting Amyloid-β Cascade in Alzheimer's DiseaseSynthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators
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description
researcher
@en
name
David Malinak
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type
label
David Malinak
@en
prefLabel
David Malinak
@en
P31
P496
0000-0002-0665-0667