about
Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity.Editing the Genome Without Double-Stranded DNA Breaks.Discovery of a Covalent Kinase Inhibitor from a DNA-Encoded Small-Molecule Library × Protein Library Selection.Rewritable multi-event analog recording in bacterial and mammalian cells.Development of hRad51-Cas9 nickase fusions that mediate HDR without double-stranded breaksAnalysis and minimization of cellular RNA editing by DNA adenine base editorsHigh-resolution specificity profiling and off-target prediction for site-specific DNA recombinasesPhage-Assisted Evolution of Bacillus methanolicus Methanol Dehydrogenase 2Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editorsContinuous evolution of SpCas9 variants compatible with non-G PAMsAdenine base editing in an adult mouse model of tyrosinaemiaSide chain determinants of biopolymer function during selection and replicationAddendum: High-resolution specificity profiling and off-target prediction for site-specific DNA recombinasesAn anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cellsSubstrate-selective inhibitors that reprogram the activity of insulin-degrading enzymeContinuous evolution of base editors with expanded target compatibility and improved activityCircularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editorsPublisher Correction: Side chain determinants of biopolymer function during selection and replicationPublisher Correction: Continuous evolution of base editors with expanded target compatibility and improved activityAuthor Correction: Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editorsHigh-throughput analysis of the activities of xCas9, SpCas9-NG and SpCas9 at matched and mismatched target sequences in human cellsCytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated virusesPrime genome editing in rice and wheatPhage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activityAuthor Correction: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activityThe developing toolkit of continuous directed evolutionIn vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness
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description
researcher
@en
wetenschapper
@nl
name
David R Liu
@en
David R Liu
@nl
type
label
David R Liu
@en
David R Liu
@nl
prefLabel
David R Liu
@en
David R Liu
@nl
P31
P496
0000-0002-9943-7557