about
An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiationMethylation of the retinoblastoma tumor suppressor by SMYD2Lung cancer signatures in plasma based on proteome profiling of mouse tumor modelsIs the Canonical RAF/MEK/ERK Signaling Pathway a Therapeutic Target in SCLC?From fly wings to targeted cancer therapies: a centennial for notch signalingA dual role for A-type lamins in DNA double-strand break repairAcute mutation of retinoblastoma gene function is sufficient for cell cycle re-entryPerp is a mediator of p53-dependent apoptosis in diverse cell typesCoexpression of normally incompatible developmental pathways in retinoblastoma genesisNfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility.Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions.Regulation of RB transcription in vivo by RB family membersp107 in the public eye: an Rb understudy and more.Functional interactions between retinoblastoma and c-MYC in a mouse model of hepatocellular carcinoma.Discovery and preclinical validation of drug indications using compendia of public gene expression data.Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 functionC/EBPbeta cooperates with RB:E2F to implement Ras(V12)-induced cellular senescence.Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscleSmyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation.G1 arrest and differentiation can occur independently of Rb family function.SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancerGenomic analysis of fibrolamellar hepatocellular carcinoma.RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo.MicroRNA programs in normal and aberrant stem and progenitor cells.Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivomiR than meets the eye.Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.Characterization of the cell of origin for small cell lung cancerpRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.Cyclin C makes an entry into the cell cycle.The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung.Loss of Pten Disrupts the Thymic Epithelium and Alters Thymic Function.A crucial requirement for Hedgehog signaling in small cell lung cancerThe retinoblastoma tumor suppressor and stem cell biology.Making young tumors old: a new weapon against cancer?Inactivating all three rb family pocket proteins is insufficient to initiate cervical cancer.PDGF signalling controls age-dependent proliferation in pancreatic β-cells.Cell type-specific effects of Rb deletion in the murine retina.Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer.Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?
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description
researcher in oncology and cancer biology and professor of pediatrics and genetics
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wetenschapper
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name
Julien Sage
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Julien Sage
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type
label
Julien Sage
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Julien Sage
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altLabel
J Sage
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prefLabel
Julien Sage
@en
Julien Sage
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P244
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0000 0001 3790 2153
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no2010077580
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P496
0000-0002-8928-9968