about
Paleovirology--modern consequences of ancient virusesNatural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivityAncient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3GThe DEAD-box RNA helicase DDX6 is required for efficient encapsidation of a retroviral genomeAntiretroelement activity of APOBEC3H was lost twice in recent human evolutionAdaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H.The range of human APOBEC3H sensitivity to lentiviral Vif proteinsThe cell cycle independence of HIV infections is not determined by known karyophilic viral elements.An evolutionary perspective on the broad antiviral specificity of MxAEvolutionary conflicts between viruses and restriction factors shape immunityEvolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus RestrictionAn evolutionary screen highlights canonical and noncanonical candidate antiviral genes within the primate TRIM gene familyHost gene evolution traces the evolutionary history of ancient primate lentivirusesThe mongoose, the pheasant, the pox, and the retrovirusBirth, decay, and reconstruction of an ancient TRIMCyp gene fusion in primate genomesThe Little Book of VirusesPaleovirology - ghosts and gifts of viruses pastThe Role of the Antiviral APOBEC3 Gene Family in Protecting Chimpanzees against Lentiviruses from MonkeysThe function and evolution of the restriction factor Viperin in primates was not driven by lentiviruses.Discordant evolution of the adjacent antiretroviral genes TRIM22 and TRIM5 in mammals.Retroviral DNA integration: viral and cellular determinants of target-site selectionEvidence for direct involvement of the capsid protein in HIV infection of nondividing cells.Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein.Genetic drift of HIV populations in culture.Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization.Evidence for a cytopathogenicity determinant in HIV-1 Vpr.Capsid is a dominant determinant of retrovirus infectivity in nondividing cells.Uracil DNA glycosylase is dispensable for human immunodeficiency virus type 1 replication and does not contribute to the antiviral effects of the cytidine deaminase Apobec3G.Dendritic cell-mediated viral transfer to T cells is required for human immunodeficiency virus type 1 persistence in the face of rapid cell turnoverReassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear importConvergence and divergence in the evolution of the APOBEC3G-Vif interaction reveal ancient origins of simian immunodeficiency viruses.How TRIM5alpha defends against retroviral invasionsRestriction of an extinct retrovirus by the human TRIM5alpha antiviral protein.Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1.A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses.Advances in HIV molecular biology.The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict.Primary isolates of human immunodeficiency virus type 1 are usually dominated by the major variants found in bloodA Single Nucleotide Polymorphism in Human APOBEC3C Enhances Restriction of LentivirusesVisualization of the intracellular behavior of HIV in living cells.
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description
researcher
@en
wetenschapper
@nl
name
Michael Emerman
@en
Michael Emerman
@nl
type
label
Michael Emerman
@en
Michael Emerman
@nl
prefLabel
Michael Emerman
@en
Michael Emerman
@nl
P31
P496
0000-0002-4181-6335