about
Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of IkarosStampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virusCorrection: Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virusCNS activity of Pokeweed anti-viral protein (PAP) in mice infected with lymphocytic choriomeningitis virus (LCMV)Protein kinase inhibitors against malignant lymphomaHigh resolution X-ray structure of potent anti-HIV pokeweed antiviral protein-IIIThe anti-leukemic Bruton's tyrosine kinase inhibitor alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl) propenamide (LFM-A13) prevents fatal thromboembolismStampidine as a promising antiretroviral drug candidate for pre-exposure prophylaxis against sexually transmitted HIV/AIDSStampidine as a novel nucleoside reverse transcriptase inhibit with potent anti-HIV activityRegulatory phosphorylation of Ikaros by Bruton's tyrosine kinaseSignal transduction through the CD19 receptor during discrete developmental stages of human B-cell ontogenyStructural requirements for potent anti-human immunodeficiency virus (HIV) and sperm-immobilizing activities of cyclohexenyl thiourea and urea non-nucleoside inhibitors of HIV-1 reverse transcriptase.Expression of a unique helios isoform in human leukemia cells.Phenylarsonic acid compounds with broad-spectrum and potent cytotoxic activity against human cancer cells.Large-scale synthesis of GMP grade alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl) propenamide (LFM-A13), a new anti-cancer drug candidate.Preclinical evaluation of a dual-acting microbicidal prodrug WHI-07 in combination with vanadocene dithiocarbamate in the female reproductive tract of rabbit, pig, and cat.Thrombopoietin induces p-selectin expression on platelets and subsequent platelet/leukocyte interactions.SYK as a New Therapeutic Target in B-Cell Precursor Acute Lymphoblastic Leukemia.STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress.In vivo toxicity, pharmacokinetics, and anti-human immunodeficiency virus activity of stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate) (stampidine) in mice.CD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells.CD22 EXON 12 deletion as a pathogenic mechanism of human B-precursor leukemiaDawn of non-nucleoside inhibitor-based anti-HIV microbicides.A PREVIOUSLY UNKNOWN UNIQUE CHALLENGE FOR INHIBITORS OF SYK ATP-BINDING SITE: ROLE OF SYK AS A CELL CYCLE CHECKPOINT REGULATORStructure-based design and engineering of a nontoxic recombinant pokeweed antiviral protein with potent anti-human immunodeficiency virus activityIn vivo antiretroviral activity of stampidine in chronically feline immunodeficiency virus-infected catsA rationally designed nanoparticle for RNA interference therapy in B-lineage lymphoid malignanciesMetvan: a novel oxovanadium(IV) complex with broad spectrum anticancer activity.Constitutive function of the Ikaros transcription factor in primary leukemia cells from pediatric newly diagnosed high-risk and relapsed B-precursor ALL patients.Recombinant human CD19L-sTRAIL effectively targets B cell precursor acute lymphoblastic leukemia.CD22ΔE12 as a molecular target for corrective repair using RNA trans-splicing: anti-leukemic activity of a rationally designed RNA trans-splicing moleculeClinical development of microbicides for the prevention of HIV infection.Tyrosine kinases as new molecular targets in treatment of inflammatory disorders and leukemia.Low Dose Total Body Irradiation Combined With Recombinant CD19-Ligand × Soluble TRAIL Fusion Protein is Highly Effective Against Radiation-Resistant B-Precursor Acute Lymphoblastic Leukemia in MiceTargeting Janus kinase 3 in the treatment of leukemia and inflammatory diseases.CD22ΔE12 as a molecular target for RNAi therapy.Development of Polypeptide-based Nanoparticles for Non-viral Delivery of CD22 RNA Trans-splicing Molecule as a New Precision Medicine Candidate Against B-lineage ALL.Liposomal Nanoparticles of a Spleen Tyrosine Kinase P-Site Inhibitor Amplify the Potency of Low Dose Total Body Irradiation Against Aggressive B-Precursor Leukemia and Yield Superior Survival Outcomes in MiceStampidine: a selective oculo-genital microbicide.Targeting JAK3 and BTK tyrosine kinases with rationally-designed inhibitors.
P50
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P50
name
Fatih M. Uckun
@en
type
label
Fatih M. Uckun
@en
prefLabel
Fatih M. Uckun
@en