about
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor.Estrogen receptor phosphorylationExtracellular signal-regulated kinase 7, a regulator of hormone-dependent estrogen receptor destruction.Development of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer.Analogs of the RSK inhibitor SL0101: optimization of in vitro biological stability.Improving the affinity of SL0101 for RSK using structure-based design.Sustained activation of the HER1-ERK1/2-RSK signaling pathway controls myoepithelial cell fate in human mammary tissueRSK2 Binding Models Delineate Key Features for ActivityRSK in tumorigenesis: connections to steroid signaling.A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA.Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation.Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survivalThree acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK.Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK.Structural basis for the activity of the RSK-specific inhibitor, SL0101.Ribosomal S6 kinase (RSK) modulators: a patent review.Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors.RNA suppression of ERK2 leads to collapse of mitochondrial membrane potential with acute oxidative stress in human lens epithelial cells.De novo synthesis and biological evaluation of C6″-substituted C4″-amide analogues of SL0101.Synthesis and Structure-Activity Relationship Study of 5a-Carbasugar Analogues of SL0101.ERα-mediated nuclear sequestration of RSK2 is required for ER+ breast cancer tumorigenesis.Novel biosensors for the detection of estrogen receptor ligands.Stereoselective Synthesis and Evaluation of C6″-Substituted 5a-Carbasugar Analogues of SL0101 as Inhibitors of RSK1/2.Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophoreRegioselective Synthesis of a C-4'' Carbamate,C-6'' n-Pr Substituted Cyclitol Analogue of SL0101The affinity of RSK for cylitol analogues of SL0101 is critically dependent on the B-ring C-4'-hydroxySynthesis and Biological Evaluation of 4'-Substituted Kaempfer-3-ols
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description
cancer researcher
@en
wetenschapper
@nl
name
Deborah A. Lannigan
@en
Deborah A. Lannigan
@nl
type
label
Deborah A. Lannigan
@en
Deborah A. Lannigan
@nl
prefLabel
Deborah A. Lannigan
@en
Deborah A. Lannigan
@nl
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P69
P1416
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0000-0001-8380-9240