about
Identification of pyrrolo[2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors.Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions and P-gp liability.RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon CancerDiscovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors
P50
description
researcher (ORCID 0000-0003-0593-2467)
@en
wetenschapper
@nl
name
Fumiyuki Shirai
@en
Fumiyuki Shirai
@nl
type
label
Fumiyuki Shirai
@en
Fumiyuki Shirai
@nl
prefLabel
Fumiyuki Shirai
@en
Fumiyuki Shirai
@nl
P31
P496
0000-0003-0593-2467