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Q27676383-4CD1626D-09E4-4EFC-951F-8A208E0AC63C
Q27676383-4CD1626D-09E4-4EFC-951F-8A208E0AC63C
BestRank
Statement
http://www.wikidata.org/entity/statement/Q27676383-4CD1626D-09E4-4EFC-951F-8A208E0AC63C
Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction
P2860
Q27676383-4CD1626D-09E4-4EFC-951F-8A208E0AC63C
BestRank
Statement
http://www.wikidata.org/entity/statement/Q27676383-4CD1626D-09E4-4EFC-951F-8A208E0AC63C
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Statement
wasDerivedFrom
f9060074ce8d872b3acc65740065b0df385d2a91
P2860
Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors