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Q33419789-03C1493E-0688-49DF-A753-22FB1A29BA86
Q33419789-03C1493E-0688-49DF-A753-22FB1A29BA86
BestRank
Statement
http://www.wikidata.org/entity/statement/Q33419789-03C1493E-0688-49DF-A753-22FB1A29BA86
MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies.
P2860
Q33419789-03C1493E-0688-49DF-A753-22FB1A29BA86
BestRank
Statement
http://www.wikidata.org/entity/statement/Q33419789-03C1493E-0688-49DF-A753-22FB1A29BA86
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wasDerivedFrom
16c0f40766e582a6474aa8d1fb4b88ef7ab75f6b
P2860
Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation