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Q46346689-375897E8-0B3C-4436-8D9F-B8E704E9F280
Q46346689-375897E8-0B3C-4436-8D9F-B8E704E9F280
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Statement
http://www.wikidata.org/entity/statement/Q46346689-375897E8-0B3C-4436-8D9F-B8E704E9F280
pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs.
P2860
Q46346689-375897E8-0B3C-4436-8D9F-B8E704E9F280
BestRank
Statement
http://www.wikidata.org/entity/statement/Q46346689-375897E8-0B3C-4436-8D9F-B8E704E9F280
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wasDerivedFrom
62208fd21c92d59bc8c5d8f96446f94e4525c2c7
P2860
Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species.