Beta-site APP cleaving enzyme 1

Beta-site APP cleaving enzyme 1

Item
http://www.wikidata.org/entity/Q14891894
Bace1
P688
Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furinAlzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid raftsMunc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processingMossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued by activation of alpha7 nicotinic acetylcholine receptorsSpatial segregation of gamma-secretase and substrates in distinct membrane domains.Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APPPicomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus.An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.The ATP-binding cassette transporter-2 (ABCA2) increases endogenous amyloid precursor protein expression and Aβ fragment generation.BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampusBisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions.The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques.Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.α-Secretase ADAM10 physically interacts with β-secretase BACE1 in neurons and regulates CHL1 proteolysis.
P921

Beta-site APP cleaving enzyme 1

Item
http://www.wikidata.org/entity/Q14891894
description
mammalian protein found in Mus musculus
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Beta-site APP cleaving enzyme 1
@nl
protèin
@ace
protéine
@fr
بروتين في فأر المنازل
@ar
name
Beta-site APP cleaving enzyme 1
@en
Beta-site APP cleaving enzyme 1
@nl
type
label
Beta-site APP cleaving enzyme 1
@en
Beta-site APP cleaving enzyme 1
@nl
altLabel
APP beta-secretase
@en
ASP2
@en
Bace1
@en
asp 2
@en
aspartyl protease 2
@en
beta-secretase 1
@en
beta-site amyloid precursor protein cleaving enzyme 1
@en
memapsin-2
@en
membrane-associated aspartic protease 2
@en
prefLabel
Beta-site APP cleaving enzyme 1
@en
Beta-site APP cleaving enzyme 1
@nl
P31
P352
P361
P527
P637
P680
P681
P682
P702
P703
P705
P352
P637
P31
P352
P361
P527
P637
P680
P681
P682
P702
P703
P705