about
P688
Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid systemSite-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signalingFcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infectionMyelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activityROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in miceInterleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinaseThe ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cellsAn immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactionsMultiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cellsShp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellumB and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediatorHomophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-SrcRole of the protein tyrosine phosphatase Shp2 in homeostasis of the intestinal epitheliumNeuronal Shp2 tyrosine phosphatase controls energy balance and metabolismSHP-2 is a novel target of Abl kinases during cell proliferation.Gab3, a new DOS/Gab family member, facilitates macrophage differentiation.Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fateConstitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathwayMegakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function.Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cellsBTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1B cell antigen receptor (BCR)-mediated formation of a SHP-2-pp120 complex and its inhibition by Fc gamma RIIB1-BCR coligationDNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphataseMice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet functionSHP-2 mediates target-regulated axonal termination and NGF-dependent neurite growth in sympathetic neuronsIdentification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cellsMouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutationLPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages.Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model.Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia developmentThe murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formation.SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity.
P921
Q24291387-60DBE3EA-65E7-42BE-9A37-464F85C05756Q24291843-9A4556EF-113B-4A8D-AF0D-F96733F60417Q24292727-7517FC32-0B5E-444A-B0E4-B58C810E2189Q24294527-0A46547D-2F21-4A2E-92F8-201913174C3FQ24298659-9AE222F1-C17E-4F63-A98C-76F30C394386Q24306141-313D417F-0811-4594-B9DA-52D9B8055CF3Q24306168-57EEE9E8-CDAB-440E-AAF7-79DE7627E77BQ24317225-0C942876-92C3-44F9-8556-865D96E6F39DQ24336788-5006CE11-C049-492B-94CE-38B4FB5FBBA9Q28292434-62AF0B61-5C10-46D2-8A45-1CB81D8EB6BEQ28506451-C74FEE99-B27B-462E-A3B7-E5B9E74C25BCQ28506619-6B0406A3-C426-485E-9CA9-F11ED39E39DDQ28508235-26F0E2C6-021D-4DA7-BFE5-9B3BA960A05FQ28508604-CB9072D5-2CE3-4B5A-B3A7-30E0C58C4186Q28511483-F56360D1-3E3E-49ED-AE57-0A517E5015F5Q28512136-673FEB87-394C-4F66-ADB7-E7C3CEFD2BC9Q28584713-EB3DB1C7-92AB-4230-8A17-D41C93EACBC5Q28584946-868FC4E1-767E-4F57-B961-F306E7282AD2Q28587068-075CFBB1-2B55-4C71-AC6F-B1BE0FFB778EQ28587122-8AB5B8B5-5357-498B-A40F-CC589346044DQ28588016-81855DFB-B1D3-46A6-A0D4-66CE91E607C8Q28589743-25FBDCA7-310B-440E-AA43-371363828881Q28589901-E321CD8D-3C23-4BD8-A7DC-C9319FA40B91Q28590697-D4096483-2609-40A0-B525-614F2B379F2BQ28592055-0152A11A-0A04-4B95-8712-0AD7EC621FFEQ28592459-F4AC6BC4-7EB1-4A17-AE8E-9D5FF2A5AB79Q28593194-FC1EE6F7-6025-406F-ADB2-A3B47BC00FADQ28594140-3D90FE48-58E0-43A4-A89C-403EA62874FDQ36229103-4B1F7BE8-4DFE-4AD6-A037-0674374CEBB9Q37368308-8DD8A9C4-20EF-4CE8-9355-CC24C195178FQ42152398-FB3C047E-3D38-47BA-B1AD-BB577D62E0ACQ51988788-4AEC1A9B-BE92-41C1-BED2-29E8D141ED52Q52592784-F25F588F-40EA-43E2-814C-DD2E5C16E82D
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Protein tyrosine phosphatase, non-receptor type 11
@nl
protèin
@ace
protéine
@fr
بروتين في فأر المنازل
@ar
name
Protein tyrosine phosphatase, non-receptor type 11
@en
type
label
Protein tyrosine phosphatase, non-receptor type 11
@en
altLabel
Ptpn11
@en
SH-PTP2
@en
SH2 domain-containing protein tyrosine phosphatase-2
@en
SHP-2
@en
Shp2
@en
protein-tyrosine phosphatase SYP
@en
tyrosine-protein phosphatase non-receptor type 11
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prefLabel
Protein tyrosine phosphatase, non-receptor type 11
@en
P361
P527
P638
P680
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P682
P352
P279
P31
P352
P361
P527
P637
NP_001103462
P638
P680
P682
P702
P703
P705
ENSMUSP00000058757
ENSMUSP00000098333