about
P688
Cellular localization of Nicastrin affects amyloid beta species productionGeneration of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrinSynaptic function of nicastrin in hippocampal neuronsConditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegenerationPresenilin 1 is required for maturation and cell surface accumulation of nicastrinER-stress-inducible Herp, facilitates the degradation of immature nicastrinModerate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilitiesPresenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brainAn E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-proteinSpatial segregation of gamma-secretase and substrates in distinct membrane domains.Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneityAPH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic developmentSorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunitsLoss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior.An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates.Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model.Pre-synaptic localization of the γ-secretase-inhibiting protein p24α2 in the mammalian brain.
P921
Q24306736-D234DBB5-1FF0-4C55-88C8-6C0A1BA87CDFQ24338484-395720FA-FF3B-449A-93D6-EC8BD8FEF6A6Q26269843-91C59F56-B881-4D1B-80AB-0DF715DB0F9AQ26269918-4FAB8130-125F-49C3-8769-4469150841C6Q28510523-A4A8FC70-3D67-4FEC-BBD3-80B40370B9E2Q28586218-0D1DD652-388F-4984-99BA-CD14CDAE091AQ28588005-653FE84E-6510-429C-B91A-6C5ED748CA6CQ28589919-2EAAA218-93FB-4AEA-9D8D-3AF15FD126DAQ28589972-CB181019-E7A2-4E56-888D-7D8B81C7E7D0Q28591973-AC94461E-3E05-4551-8B66-F3236A80717FQ28592098-25525E7C-8A2C-4A3C-BDBD-5EFB52D15CFEQ28592373-49B70A6D-440F-4A56-8AB7-3C5482C9DC54Q28594188-E98CE5C1-9851-44FC-B136-A12C655B88A4Q30762130-74BCC3E5-F1F1-4737-B468-828587A358F3Q35084401-C67E9DF6-6494-47CE-B31A-61B2228D00C3Q35169524-E437C8B3-7326-46C2-BAEC-9F73534595E7Q39849120-EE81D7BA-C626-4D27-BAB0-569F825D5072Q46527301-E7DAEE14-9ADA-4220-866E-3B69470E23D1Q48442103-C9841E8A-7CB6-402A-BD27-46EBDDF396EA
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Nicastrin
@nl
protèin
@ace
protéine
@fr
بروتين في فأر المنازل
@ar
name
Nicastrin
@en
type
label
Nicastrin
@en
altLabel
Ncstn
@en
nicastrin
@en
uniprot:P57716
@en
prefLabel
Nicastrin
@en
P361
P637
P680
P681
P682
P705
P352
P31
P352
P637
XP_006497015
XP_017177361
P681
P682
P702
P703
P705
ENSMUSP00000003550
ENSMUSP00000119128
ENSMUSP00000120663