about
P688
Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zetaCloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activityStructural studies reveal an important role for the pleiotrophin C-terminus in mediating interactions with chondroitin sulfateA heparin-binding growth factor secreted from breast cancer cells homologous to a developmentally regulated cytokineRole of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATIONOsteocyte-derived HB-GAM (pleiotrophin) is associated with bone formation and mechanical loading.Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta.The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice
P921
Q22253290-C50DAFA3-8D19-4E98-A9E5-EB2DD0A85DC9Q24338373-25BC3001-2C8F-4B00-9271-888236E5A27CQ27704056-2352D810-863F-4E38-ABD1-13FD55D685BAQ28118874-E5C7B719-895A-4645-A580-E3E4FAB8B599Q39573196-8AC7E809-97C1-4D10-BCFB-B0E5237D744DQ39851510-29545F9F-09A5-4B47-8CC1-617DF3D3268BQ45904605-933A5D86-982F-43AA-BD68-02A498F47AFFQ91152885-A0DDA142-0C5E-4C6B-B205-9E200C1DC0F9
P921
description
humanes Protein
@de
mammalian protein found in Homo sapiens
@en
menselijk eiwit
@nl
protein
@id
protein
@sv
proteinë
@sq
protèin
@ace
protéine humaine
@fr
بروتين بشري
@ar
name
Pleiotrophin
@en
Pleiotrophin
@nl
Pleiotrophine
@fr
type
label
Pleiotrophin
@en
Pleiotrophin
@nl
Pleiotrophine
@fr
altLabel
HB-GAM
@en
HBBM
@en
HBGF-8
@en
HBNF-1
@en
OSF-1
@en
PTN
@en
heparin affin regulatory protein
@en
heparin-binding brain mitogen
@en
heparin-binding growth factor 8
@en
heparin-binding growth-associated molecule
@en
prefLabel
Pleiotrophin
@en
Pleiotrophin
@nl
Pleiotrophine
@fr
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NP_001308315
NP_001308316
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ENSP00000341170
ENSP00000376798