Platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
about
P688
The Pafah1b complex interacts with the reelin receptor VLDLRHippocampal abnormalities and enhanced excitability in a murine model of human lissencephalyLIS1, CLIP-170's key to the dynein/dynactin pathway.Systematic analysis of human protein complexes identifies chromosome segregation proteinsThe structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephalyA human interactome in three quantitative dimensions organized by stoichiometries and abundances.A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous systemNUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndromeInteraction of reelin signaling and Lis1 in brain developmentLis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells.Lis1 is necessary for normal non-radial migration of inhibitory interneuronsDisregulated RhoGTPases and actin cytoskeleton contribute to the migration defect in Lis1-deficient neuronsCytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway.Lis1 controls dynamics of neuronal filopodia and spines to impact synaptogenesis and social behaviourPostnatal alterations of the inhibitory synaptic responses recorded from cortical pyramidal neurons in the Lis1/sLis1 mutant mouseTargeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerizationA study of the nature of embryonic lethality in LIS1-/- miceLis1-Nde1-dependent neuronal fate control determines cerebral cortical size and laminationDISC1, PDE4B, and NDE1 at the centrosome and synapseLis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization.Impaired learning and motor behavior in heterozygous Pafah1b1 (Lis1) mutant miceThe lissencephaly protein Lis1 is present in motile mammalian cilia and requires outer arm dynein for targeting to Chlamydomonas flagellaTargeted disruption of intracellular type I platelet activating factor-acetylhydrolase catalytic subunits causes severe impairment in spermatogenesisInactivation of a testis-specific Lis1 transcript in mice prevents spermatid differentiation and causes male infertilityMultiple dose-dependent effects of Lis1 on cerebral cortical developmentNudE-L, a novel Lis1-interacting protein, belongs to a family of vertebrate coiled-coil proteinsNudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cellsRecruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migrationComplete loss of Ndel1 results in neuronal migration defects and early embryonic lethality.A role for cytoplasmic dynein and LIS1 in directed cell movementLis1 is essential for cortical microtubule organization and desmosome stability in the epidermisGraded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethalityLIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1
P921
Q21144460-2A37AACD-7C3E-494C-9850-5764E56DD15EQ22253373-94A87C1E-351C-4390-A618-6260265CF5B6Q24293597-91851EA9-D2D1-4B30-8910-4C2A08BF5712Q24305303-7E8FA893-E8C9-4930-BA80-9BA983C5DE0BQ27649018-88780BED-887B-40DE-ACE5-74FB8D24A12FQ27936244-AF04E700-A3F3-41D3-8344-4D4986878904Q28143518-689FD7BB-F35F-4DA4-BB4F-42A65F3CD43CQ28143527-F504397E-F932-4593-85C0-85755B90B87FQ28178021-159EC3AE-04AB-40D0-96BE-3BBBAD9ED264Q28212561-15B26DFA-3E7B-4C43-BB79-F604F241E5F4Q28505388-83B0B40B-11AA-455D-A7EF-A59E6363083FQ28507800-555CF159-B403-4737-A9B8-BA4F314D33EAQ28507967-1990DF1A-303A-4646-BF29-F68B893F78B5Q28508499-AB3A23FF-A0BC-458D-834B-F1DB345BC576Q28509621-ECC445E1-0CEA-4C0C-B620-684E115C01A9Q28511084-E8218F4A-C9CC-4F55-8F74-31BCFF8A11CDQ28511877-FABE7E44-2239-4379-88A1-89DC716E5E39Q28513156-A53C671E-B3FE-4489-989B-4A8938D61A55Q28584948-37972FB8-CCE2-4F89-933B-FE7E409F590BQ28585118-07208F11-7EAF-4AEF-97A6-FEC1527165A4Q28585571-5ECBF02B-6EB9-443B-87CC-23A4ACD2BE6EQ28585670-CA5901CF-C999-4691-BDB9-0574B5C59A4BQ28588190-3DA32939-72D0-4C21-877E-B0B3CCBF8EA4Q28588411-1D991349-C4F3-4549-8616-DE0727660744Q28589208-0AF42790-82A1-464D-A8E7-AF06BBD5F285Q28589891-638EA05A-13F6-4070-BD49-AD6467604069Q28590012-528F0DC4-DDB6-4BB3-B578-9B6A781FFB8AQ28590080-3D66FEB8-403D-4372-89EB-A61090230AD2Q28590739-F105BC0D-B115-4516-B5D5-F8BBE70BEE2EQ28591177-1A9E9493-B9B3-49D2-8F57-BAF2CA7E26D2Q28591271-E2B1E13B-851D-4161-86E3-AF86C027CCE8Q28591979-3402B660-A2D2-488A-8A97-5010289B768EQ28592982-17530B6B-0388-43E4-8444-8DFF4D1F36CBQ28593263-FF50164E-8B4C-4E15-9EBE-5C2D446E820E
P921
Platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
description
mammalian protein found in Mus musculus
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
@nl
protèin
@ace
protéine
@fr
بروتين في فأر المنازل
@ar
name
Platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
@en
Platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
@nl
type
label
Platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
@en
Platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
@nl
altLabel
LIS-1
@en
PAF acetylhydrolase 45 kDa subunit
@en
PAF-AH 45 kDa subunit
@en
PAF-AH alpha
@en
PAFAH alpha
@en
Pafah1b1
@en
Pafaha/Lis1
@en
lissencephaly-1 protein
@en
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1
@en
platelet-activating factor acetylhydrolase 45kD subunit
@en
prefLabel
Platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
@en
Platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
@nl
P361
P527
P680
P681
P682
P705
P352
P637
P31
P352
P361
P527
P637
P680
P681
P682
P702
P703
P705
ENSMUSP00000021091
ENSMUSP00000099578
ENSMUSP00000118231