sameAs
P688
siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscleColocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes. Cholesterol depletion blocks insulin signalling for metabolic and mitogenic controlActivation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responsesAdapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interactionPhosphorylation of IRS1 at serine 307 and serine 312 in response to insulin in human adipocytesPhosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domainNon-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptorThe p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complexDistinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domainsOverexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosisGrowth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinomaC1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy.
P921
Q50255837-5831A7DA-EC52-4537-8D40-C609C6F50861Q50263256-32CF5115-A11E-42B6-8FB1-EBB89A4AA220Q50263607-2E4801C6-BB6C-416E-B439-1BA8452A12D8Q50263813-41FB4816-FE29-4550-BF2A-FD63AF91D07BQ50271407-44BE0E8B-457D-4922-B801-3026AF3AF738Q50272063-64BC73D8-24EE-4238-9B1C-AEC017B2E23FQ50272072-84EA9D43-8B98-4EA4-AA10-1048EEE4620EQ50272076-017EAAA8-2832-48D2-9DD7-57D63F9522F9Q56856783-5DB5CA1B-8F68-436E-8997-2F59F5CA3DD5Q56860668-5E0C2D91-E865-4F97-9DD6-47E807805FE8
P527
Q24295160-0D1C2DCD-9B0D-46E4-AC38-E5155CFA3304Q24295215-BB0116FD-6EC9-406F-BD53-51A3FF4FA731Q24297068-93B0689A-6A1E-437A-B852-F746CF9582E3Q24304168-E566029E-6DA8-4BC0-9C1D-A2285B34DE91Q24306570-94B09E15-838F-47EB-BDB0-48BA55A06AE6Q24307071-1A83698F-41A0-437C-AD21-4B9C03930A3DQ24307508-3A1F80F3-1A56-4391-B7CF-CF9DC8C1DE3FQ24310123-9660C64F-785B-4F44-B0E7-A22C79D8EEC9Q24310517-71571116-9A02-4DC3-9D8E-442107062F46Q24317713-468C8C29-98C4-4AFF-B0AA-22F4D0070A81Q24322608-3BE8B8C1-7EB3-4E2B-BDB6-ECD86238D0ABQ24328787-C122BCAE-4689-4E5C-8A18-DBB3DE589C47Q36759853-103D659F-D157-47C6-8418-7A320B33DF01
P921
description
Protein
@de
mammalian protein found in Homo sapiens
@en
menselijk eiwit
@nl
protein
@id
protein
@sv
proteinë
@sq
protèin
@ace
protéine
@fr
بروتين بشري
@ar
name
IRS1
@it
Insuliinireseptorisubstraatti 1
@fi
Insulin receptor substrate 1
@en
Insulin receptor substrate 1
@nl
Insulin-Rezeptor-Substrat
@de
ركيزة مستقبلة الإنسولين
@ar
インスリン受容体基質
@ja
type
label
IRS1
@it
Insuliinireseptorisubstraatti 1
@fi
Insulin receptor substrate 1
@en
Insulin receptor substrate 1
@nl
Insulin-Rezeptor-Substrat
@de
ركيزة مستقبلة الإنسولين
@ar
インスリン受容体基質
@ja
altLabel
IRS-1
@en
IRS-1
@fi
IRS1
@en
insulin receptor substrate 1
@en
uniprot:P35568
@en
ركيزة مستقبل الإنسولين
@ar
prefLabel
IRS1
@it
Insuliinireseptorisubstraatti 1
@fi
Insulin receptor substrate 1
@en
Insulin receptor substrate 1
@nl
Insulin-Rezeptor-Substrat
@de
ركيزة مستقبلة الإنسولين
@ar
インスリン受容体基質
@ja
P638
P680
P681
P682
P352
P486
P6366
P637
P31
P352
P486
P6366
P637
P638
P680
P681
P682
P702
P703
P705
ENSP00000304895