A Conversation with Susan Band HorwitzTermination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule CatastrophesHigh expression of class III β-tubulin predicts good response to neoadjuvant taxane and doxorubicin/cyclophosphamide-based chemotherapy in estrogen receptor-negative breast cancerTotal Synthesis of(–)-Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the EpothilonesDirect analysis of tubulin expression in cancer cell lines by electrospray ionization mass spectrometry.A label-free mass spectrometry method for relative quantitation of β-tubulin isotype expression in human tumor tissue.Detection of human betaV-tubulin expression in epithelial cancer cell lines by tubulin proteomics.Tubulin proteomics: towards breaking the code.Methods in tubulin proteomicsPotentiation of taxol efficacy and by discodermolide in ovarian carcinoma xenograft-bearing miceMechanisms of Taxol resistance related to microtubules.Stathmin/Op18 is a novel mediator of vinblastine activity.Insulin-like growth factor 2 expression modulates Taxol resistance and is a candidate biomarker for reduced disease-free survival in ovarian cancer.The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence.Design and synthesis of (+)-discodermolide-paclitaxel hybrids leading to enhanced biological activityEpothilone B enhances surface EpCAM expression in ovarian cancer Hey cellsNovel molecules that interact with microtubules and have functional activity similar to Taxol.Resistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1-dependent.Exploiting MEK inhibitor-mediated activation of ERα for therapeutic intervention in ER-positive ovarian carcinoma.Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation.Insights into the mechanism of microtubule stabilization by Taxol.Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescenceEribulin disrupts EB1-microtubule plus-tip complex formationSynthesis and Biological Evaluation of Novel 3'-Difluorovinyl Taxoids.Increased levels of a unique post-translationally modified betaIVb-tubulin isotype in liver cancerTissue microarray analysis of hormonal signaling pathways in uterine carcinosarcomaExploring the mechanisms of action of the novel microtubule inhibitor vinflunine.Structural evidence for cooperative microtubule stabilization by Taxol and the endogenous dynamics regulator MAP4.2-(m-Azidobenzoyl)taxol binds differentially to distinct β-tubulin isotypesDesign, synthesis, and biological evaluation of new-generation taxoidsDesign, synthesis, and biological evaluation of novel C14-C3'BzN-linked macrocyclic taxoids.Proteomics of cancer cell lines resistant to microtubule-stabilizing agents.TP53 hot spot mutations in ovarian cancer: selective resistance to microtubule stabilizers in vitro and differential survival outcomes from The Cancer Genome Atlas.Nature as a remarkable chemist: a personal story of the discovery and development of Taxol.Structural Basis of Microtubule Stabilization by Discodermolide.Characterization of a human βV-tubulin antibody and expression of this isotype in normal and malignant human tissue.The interaction between mitotic checkpoint proteins, CENP-E and BubR1, is diminished in epothilone B-resistant A549 cells.Wild-type class I beta-tubulin sensitizes Taxol-resistant breast adenocarcinoma cells harboring a beta-tubulin mutation.A highly epothilone B-resistant A549 cell line with mutations in tubulin that confer drug dependence.Enhancement of the therapeutic efficacy of taxol by the mitogen-activated protein kinase kinase inhibitor CI-1040 in nude mice bearing human heterotransplants.
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description
American biochemist
@en
US-amerikanische Biochemikerin und Pharmakologin
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scheikundige
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name
S.B.霍維茨
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S.B.霍维茨
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S.B.霍维茨
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S.B.霍维茨
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Susan Band Horwitz
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Susan Band Horwitz
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Susan Band Horwitz
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Susan Band Horwitz
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Susan Band Horwitz
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Susan Band Horwitz
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S.B.霍維茨
@zh-hant
S.B.霍维茨
@zh
S.B.霍维茨
@zh-cn
S.B.霍维茨
@zh-hans
Susan Band Horwitz
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Susan Band Horwitz
@de
Susan Band Horwitz
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Susan Band Horwitz
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Susan Band Horwitz
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Susan Band Horwitz
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S.B.霍維茨
@zh-hant
S.B.霍维茨
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S.B.霍维茨
@zh-cn
S.B.霍维茨
@zh-hans
Susan Band Horwitz
@ast
Susan Band Horwitz
@de
Susan Band Horwitz
@en
Susan Band Horwitz
@es
Susan Band Horwitz
@ga
Susan Band Horwitz
@sl
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