Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study
about
Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, ChinaGenome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease riskUnmet Needs in LDL-C Lowering: When Statins Won't Do!Mendelian randomization studies: a review of the approaches used and the quality of reportingMechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease riskMendelian randomization to assess causal effects of blood lipids on coronary heart disease: lessons from the past and applications to the futureIdentification and functional characterization in vivo of a novel splice variant of LDLR in rhesus macaquesEvaluating the causal relevance of diverse risk markers: horizontal systematic reviewLarge-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.Mendelian Randomization as an Approach to Assess Causality Using Observational Data.Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts.Meta-analysis of low density lipoprotein receptor (LDLR) rs2228671 polymorphism and coronary heart disease.Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment.Usefulness of Mendelian randomization in observational epidemiology.Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatinGenetic causes of myocardial infarction: new insights from genome-wide association studies.Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance.Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls.Familial hypercholesterolemia: Molecular characterization of possible cases from the Azores Islands (Portugal).Multiple associated variants increase the heritability explained for plasma lipids and coronary artery disease.The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients.Genetic Polymorphisms in the Dopamine Receptor 2 Predict Acute Pain Severity after Motor Vehicle Collision.Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease.A Splice Region Variant in LDLR Lowers Non-high Density Lipoprotein Cholesterol and Protects against Coronary Artery Disease.Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies.Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studiesLDLR and PCSK9 Are Associated with the Presence of Antiphospholipid Antibodies and the Development of Thrombosis in aPLA CarriersCredible Mendelian randomization studies: approaches for evaluating the instrumental variable assumptionsMendelian randomization in nutritional epidemiologyEmerging LDL therapies: Using human genetics to discover new therapeutic targets for plasma lipids.Low density lipoprotein receptor polymorphisms and the risk of coronary heart disease: the Atherosclerosis Risk in Communities Study.Molecular signatures of cardiovascular disease risk: potential for test development and clinical application.Selecting instruments for Mendelian randomization in the wake of genome-wide association studies.Translating genomic analyses into improved management of coronary artery disease.Genetics and personalized medicine--a role in statin therapy?Mendelian randomisation applied to drug development in cardiovascular disease: a review.Ancestral experience as a game changer in stress vulnerability and disease outcomes.Genetic risk factors and Mendelian randomization in cardiovascular disease.
P2860
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P2860
Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study
description
2008 nî lūn-bûn
@nan
2008 թուականին հրատարակուած գիտական յօդուած
@hyw
2008 թվականին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Lifelong reduction of LDL-chol ...... Mendelian Randomisation study
@ast
Lifelong reduction of LDL-chol ...... Mendelian Randomisation study
@en
Lifelong reduction of LDL-chol ...... Mendelian Randomisation study
@en-gb
Lifelong reduction of LDL-chol ...... Mendelian Randomisation study
@nl
type
label
Lifelong reduction of LDL-chol ...... Mendelian Randomisation study
@ast
Lifelong reduction of LDL-chol ...... Mendelian Randomisation study
@en
Lifelong reduction of LDL-chol ...... Mendelian Randomisation study
@en-gb
Lifelong reduction of LDL-chol ...... Mendelian Randomisation study
@nl
prefLabel
Lifelong reduction of LDL-chol ...... Mendelian Randomisation study
@ast
Lifelong reduction of LDL-chol ...... Mendelian Randomisation study
@en
Lifelong reduction of LDL-chol ...... Mendelian Randomisation study
@en-gb
Lifelong reduction of LDL-chol ...... Mendelian Randomisation study
@nl
P2093
P2860
P50
P3181
P1433
P1476
Lifelong reduction of LDL-chol ...... Mendelian Randomisation study
@en
P2093
Angela Doering
Anika Götz
Arne Schaefer
Christian Roth
Diana Rubin
Ingrid Braenne
Iris M Heid
Jan Ortlepp
Jürgen Schrezenmeier
Jürgen Schrezenmeir
P2860
P3181
P356
10.1371/JOURNAL.PONE.0002986
P407
P50
P577
2008-01-01T00:00:00Z