P688
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinaseRho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loopSpecific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinaseRho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarityDynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes.Rocks: multifunctional kinases in cell behaviourIdentification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damageIdentification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinaseThe Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbingInhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesisTumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phasesPhosphorylation of profilin by ROCK1 regulates polyglutamine aggregationDistinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiationOdontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA SignalingFibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunctionRho-associated coiled-coil kinase (ROCK) protein controls microtubule dynamics in a novel signaling pathway that regulates cell migrationRho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of FunctionPharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model.ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance.
P921
Q22010473-4B5EBA66-2D5B-47A4-97C1-EC7C5F1518A0Q22011174-DC7077AC-8703-45D1-AB6C-F5FDE482B0C2Q24290361-82FCA7BE-7A10-46A3-A58C-85D08AC7E1D5Q24298069-A7DDC638-2995-428A-A08E-A155F92AC1AEQ24300262-0BE75E4C-12CE-48D5-A412-C45B01763E1AQ24303641-F9DDB666-B501-43B7-A3C8-2C283A9F6BA0Q24318504-D40B7921-971D-4F0E-8EC1-707A903A537DQ24321633-910EFA8C-48E8-41A9-BD44-F7421A1F5E10Q24322829-12A5DC02-9D54-453D-B892-F3AB20EF7B11Q24323982-285AFB6A-6FD9-4793-8152-E027CF910AEEQ24324864-F3BE2AAA-2A0F-4062-9A50-14FBB210365CQ24324878-8CF88F12-EFDD-43A4-8477-E7705DDA880DQ24337057-95EEE5E6-0A92-44C7-826B-6B27767EC280Q24337081-BB84A339-ED99-4E9D-9270-00405CA29047Q33877795-D67459AB-742C-46C6-9E02-E824A2A0FF19Q36481811-3D9B879F-4330-4E6F-92FA-AC38F9A24701Q37042653-60DDFA92-EB92-4AED-BC70-4DC0072E8292Q37362443-3C9B48BB-CBAB-46DE-AB1F-B979CA0ACA76Q37385622-39A11BC5-69B0-4F76-8861-7A5EE3DB41AE
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Rho associated coiled-coil containing protein kinase 1
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
ROCK1
@uk
Rho associated coiled-coil containing protein kinase 1
@en
Rho associated coiled-coil containing protein kinase 1
@nl
Rho-Kinase 1
@de
type
label
ROCK1
@uk
Rho associated coiled-coil containing protein kinase 1
@en
Rho associated coiled-coil containing protein kinase 1
@nl
Rho-Kinase 1
@de
altLabel
ROCK-I
@en
ROCK1
@en
Rho-associated, coiled-coil-containing protein kinase 1
@en
Rho-associated, coiled-coil-containing protein kinase I
@en
p160 ROCK-1
@en
p160ROCK
@en
renal carcinoma antigen NY-REN-35
@en
rho-associated protein kinase 1
@en
prefLabel
ROCK1
@uk
Rho associated coiled-coil containing protein kinase 1
@en
Rho associated coiled-coil containing protein kinase 1
@nl
Rho-Kinase 1
@de
P361
P527
P638
P680
P681
P682
P705
P352
P6366
P637
P31
P352
P361
P527
P6366
P637
P638
P680
P681
P682
P702
P703
P705
ENSP00000382697
ENSP00000462004
ENSP00000489185