Polycystin 2, transient receptor potential cation channel
P688
Specific association of the gene product of PKD2 with the TRPC1 channelThe polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeletonCellular and subcellular distribution of polycystin-2, the protein product of the PKD2 genePolycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channelPolycystin-2 is an intracellular calcium release channelExpression of PKD1 and PKD2 transcripts and proteins in human embryo and during normal kidney developmentTrafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulationPolycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexesAlpha-actinin associates with polycystin-2 and regulates its channel activityPericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assemblyThe human polycystin-2 protein represents an integral membrane protein with six membrane-spanning domains and intracellular N- and C-terminiEffect of hydro-osmotic pressure on polycystin-2 channel function in the human syncytiotrophoblastAssociation of PKD2 (polycystin 2) mutations with left-right laterality defectsHomo- and heterodimeric interactions between the gene products of PKD1 and PKD2Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cellsCiliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascadesPolycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alphaPRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradationReactive oxygen species inhibit polycystin-2 (TRPP2) cation channel activity in term human syncytiotrophoblastCentrosome overduplication and mitotic instability in PKD2 transgenic linesPolycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signalingPKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindlesA high-resolution structure of the EF-hand domain of human polycystin-2Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutantMolecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2The cAMP Signaling Pathway and Direct Protein Kinase A Phosphorylation Regulate Polycystin-2 (TRPP2) Channel FunctionThe polycystin complex mediates Wnt/Ca(2+) signalling.Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels.Structure of the human PKD1-PKD2 complex
P921
Q22009113-C1A4A908-263C-42E9-869E-AC7505C8795DQ22253865-F98591C9-5CC2-4F21-A2D5-1A3AE48C62B5Q22253927-FDD66DCF-A93A-4966-AE41-48730B1EFBABQ24290926-CCA6F009-9899-4E7C-BCAE-4F451BA998EAQ24292332-75323EAD-DFF3-47DA-90D2-96A7F87D70E1Q24292456-90DB7831-18EF-4714-9DC7-26025CC908F4Q24293752-E9C3E689-27BB-4E35-B4F4-A270426BBDF2Q24297056-B4179D5D-35D6-46EF-8323-B37FD7896B88Q24300157-D0339CE9-A8AE-4044-9E3A-31741CE6F908Q24300429-9B57057F-CDA7-4764-8870-42ECFDB149FFQ24302124-95742571-9D21-4186-B449-80A5E6D6EE8EQ24305249-E55E9032-D284-4757-B892-4E25E61BCE43Q24308028-6805C059-CC7D-4061-89E0-581E22CF97E8Q24308809-872146B3-7051-428A-9CE4-7AA8D9490E16Q24311425-1D158778-284F-49A1-8ADA-2444EA9CC45AQ24314239-C389B156-B21F-40B4-BA89-203B64EEE0E2Q24318379-8F31916C-7592-4B4E-AD3B-85D88453A242Q24318555-B10CCFD6-1075-46D4-9919-DFD0D7D6B73BQ24321394-4B03E0BD-A1B1-4EB4-A382-47810AE1F50CQ24321997-1863A4C5-DCC6-4B8D-99DD-5098801B658DQ24336465-4B1B8681-CB66-4173-B2CD-8DCAC1197AF7Q24338262-FB4B0078-011D-4B0D-9528-5F6AF631392CQ24338591-2C572181-69E0-4BB7-BB6B-BE20870035C1Q27684526-5712CF39-E476-4720-98BE-94A2B59AB366Q29147455-BCF195EA-62CB-4418-A8D1-C1423F3BA385Q29147506-DA8DC0C2-8A0E-4C13-9BCF-8DA885384B6BQ29147515-B9C07847-9EC5-4AA6-8C24-6E2A3CDF079AQ37047803-6CF2C46D-540B-4023-A3D0-B90A0652A10CQ55162200-7A089044-0166-42D3-AE4E-E65BF66BDCE4Q68711902-C6FC430E-5292-4DDD-80A3-1EE28FD7E3F9
P921
Polycystin 2, transient receptor potential cation channel
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Polycystin 2, transient receptor potential cation channel
@nl
protèin
@ace
بروتين في الإنسان العاقل
@ar
name
PKD2
@de
PKD2
@uk
Polycystin 2, transient receptor potential cation channel
@en
type
label
PKD2
@de
PKD2
@uk
Polycystin 2, transient receptor potential cation channel
@en
altLabel
PKD2
@en
Polycystic kidney disease 2 protein
@en
R48321
@en
autosomal dominant polycystic kidney disease type II protein
@en
polycystic kidney disease 2 (autosomal dominant)
@en
polycystin-2
@en
polycystwin
@en
transient receptor potential cation channel subfamily P member 2
@en
prefLabel
PKD2
@de
PKD2
@uk
Polycystin 2, transient receptor potential cation channel
@en
P361
P637
P638
P680
P681
P682
P705
P352
P2888
P31
P352
P361
P637
XP_011530330
XP_011530331
XP_011530332
P638
P680
P681
P682
P702
P703
P705
ENSP00000237596
ENSP00000425289
ENSP00000427131