about
P688
Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymesHuman Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunitsNuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substratesNEDD4-1 is a proto-oncogenic ubiquitin ligase for PTENUbiquitination regulates PTEN nuclear import and tumor suppressionThe KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like familyHECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACKDamage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytesCalcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteinsPMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progressionThe C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localizationYeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptorsNedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage responseSIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth diseaseTransport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitinationISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activityNedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptorNedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus buddingDeubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesisNedd4 E3 ubiquitin ligase promotes cell proliferation and autophagyE3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1
P921
Q22001440-47084077-B1CF-4715-9497-45B2992A8C75Q22011107-49CFC9FD-57BC-4E7D-A346-97A2F55A02F4Q24291211-F8977B00-E7C5-4533-A8C6-0A3594437CE8Q24292919-2D253E69-DCD1-4D19-AA8B-7ED64F9F1181Q24292946-E8E05E3F-888F-433E-AED3-89DD74DF2A68Q24296263-842A20E9-6136-4E1F-BC5D-3AED10F871DFQ24296458-35106E7C-9BD8-48DA-AF4D-43909E75CCC6Q24300146-702BF5AA-EEF9-476D-9EDA-AA43E4872741Q24304246-E2C2CE1C-DF96-421F-B9F6-4A2A0FD286BEQ24310048-A1B97941-3A48-4406-B2D9-C332545D4F01Q24314303-E6BCF598-90C6-4C99-9478-F6BF02D16550Q24314678-06CDDCBF-9189-4744-BE24-2F4D9DA1181FQ24316214-2B722C5E-6FA0-4CA1-8CFF-6479F5737BEFQ24316324-1E8778F6-56D1-4F4F-A1B9-E5D889638A1DQ24317547-BBE381CB-6360-47E7-A4C9-37D6BABE4F04Q24318243-E23864BF-015E-4A4A-A144-38073CBED456Q24318462-D63CEBD9-DB7B-4038-96E9-91E5A65A2F1BQ24320318-725BB384-41B1-4E13-A00C-54EF26EE4C8EQ24338693-C335A43B-8E84-4046-9AEF-9F4C173EF238Q28117749-27A878E8-60A1-4DCE-827D-4082237EA5A3Q28119201-2A683FB5-C1D2-455C-968B-8A1A05BE9F87Q28547141-7CCAED4E-4854-4B40-B2DC-33EA1B9E4DB3Q36835064-EF372642-B6D9-49C3-A4A3-7AB98DD31E06
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Neural precursor c ...... 4, E3 ubiquitin protein ligase
@nl
protèin
@ace
بروتين في الإنسان العاقل
@ar
name
NEDD4 E3 ubiquitin protein ligase
@en
NEDD4 E3 ubiquitin protein ligase
@nl
type
label
NEDD4 E3 ubiquitin protein ligase
@en
NEDD4 E3 ubiquitin protein ligase
@nl
altLabel
E3 ubiquitin-protein ligase NEDD4
@en
HECT-type E3 ubiquitin transferase NEDD4
@en
NEDD-4
@en
NEDD4
@en
Neural precursor cell expressed developmentally down-regulated protein 4
@en
cell proliferation-inducing gene 53 protein
@en
neural precursor cell expresse ...... 4, E3 ubiquitin protein ligase
@en
receptor-potentiating factor 1
@en
prefLabel
NEDD4 E3 ubiquitin protein ligase
@en
NEDD4 E3 ubiquitin protein ligase
@nl
P361
P637
P638
P680
P681
P682
P705
P352
P637
P31
P352
P361
P637
NP_001271267
NP_001271268
NP_001271269
NP_001316141
XP_011519926
XP_011519927
XP_011519928
P638
P680
P681
P682
P702
P703
P705
ENSP00000345530
ENSP00000410613
ENSP00000421047
ENSP00000422455
ENSP00000422705
ENSP00000424471
ENSP00000424827
ENSP00000426051
ENSP00000498181
P7260
8.A.30.1.2