about
NOTCH1 PEST domain mutants stimulate HES1 transcriptionHEY1;HEY2;HES1HES1:TLEHNF6-dependent synthesis of NEUROG3 protein during morphogenesisRBPJ- and NOTCH1-dependent synthesis of HES1 protein during morphogenesisHES1 gene transcription is inhibited by RUNX3NOTCH1 stimulates HES1 transcriptionHES1 binds TLENOTCH2 stimulates HES1 transcriptionHES1 gene expression is stimulated by NOTCH3 and STAT1HES1 gene expression is stimulated by NOTCH4
P527
P688
Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repressionOverexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterationsGenomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairyIntegrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancerStructure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elementsConservation of the Notch1 signaling pathway in gastrointestinal carcinoid cellsNotch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells
P921
Q37753138-4B672239-960C-469A-A1BB-77D8F6AEC798Q50258486-6328C2C1-66C3-4BE7-A074-B15B7FE7C7EFQ50273325-BD9AF7D6-7FB7-4364-80B1-F90F0A2AC46EQ50287839-8D8C5BBB-F9A6-4FFF-A57F-E29C7CB4D705Q50287840-1B536397-26B1-486F-86D8-8058B2E589EFQ50290746-5E8E0BE7-B2D4-4DA8-AC31-9CD7872FF1FFQ50290748-48B1BE2B-3EB1-4B89-8A7E-1A8616D0AD5BQ50298645-92209347-43C2-4B13-BECB-0AA807E3DDEEQ50298672-0E0E282E-8643-40CA-9F5A-50B26D70E414Q55219519-725106EA-C032-403A-A2BF-B0D621239928Q56860731-E90F9516-EE58-4A0F-9457-F1F63B48EB4B
P527
Q24292887-9F612B26-5CF9-4ADC-810A-4FAA9F69316EQ24298328-E433F1A2-B197-4826-ADCB-419A0EAAFB32Q24313079-8479B15B-ACB7-4D06-958A-C6324FF7FA56Q24317103-3A048CC5-097B-435E-9774-988A3955F07EQ24318691-7AC834BE-E232-4F27-A229-E1F6DB14917DQ24323223-48C219EB-72C3-48DD-857C-D65A9F999419Q24329090-E7E424F3-1FD7-491C-9119-48B003080F2E
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
proteinë
@sq
proteïne in Hes family bHLH transcription factor 1
@nl
protèin
@ace
بروتين في الإنسان العاقل
@ar
在智人中發現的哺乳動物蛋白質
@zh
name
Hes family bHLH transcription factor 1
@en
Hes family bHLH transcription factor 1
@nl
type
label
Hes family bHLH transcription factor 1
@en
Hes family bHLH transcription factor 1
@nl
altLabel
HES1
@en
Hairy and enhancer of split 1
@en
bHLHb39
@en
class B basic helix-loop-helix protein 39
@en
hHL
@en
hairy homolog
@en
hairy-like protein
@en
transcription factor HES-1
@en
prefLabel
Hes family bHLH transcription factor 1
@en
Hes family bHLH transcription factor 1
@nl
P680
P681
P682
P352
P486
P637
P638
P31
P352
P486
D000072056
P637
P680
P682
P702
P703
P705
ENSP00000232424