KRIT1 regulates the homeostasis of intracellular reactive oxygen species
about
Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stressLoss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformationsCerebral Cavernous Malformations: Review of the Genetic and Protein-Protein Interactions Resulting in Disease PathogenesisMitochondria-ros crosstalk in the control of cell death and agingIdentification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1KLF4 is a key determinant in the development and progression of cerebral cavernous malformations.The pathobiology of vascular malformations: insights from human and model organism genetics.KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling.Sclerotial formation of Polyporus umbellatus by low temperature treatment under artificial conditionsStrategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation.Proteomic analysis reveals KRIT1 as a modulator for the antioxidant effects of valproic acid in human bone-marrow mesenchymal stromal cells.Defective autophagy is a key feature of cerebral cavernous malformations.Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1.Roles for ROS and hydrogen sulfide in the longevity response to germline loss in Caenorhabditis elegans.Mitochondrial reactive oxygen species-mediated genomic instability in low-dose irradiated human cells through nuclear retention of cyclin D1.Introduction to cerebral cavernous malformation: a brief review.Cerebral cavernous malformation proteins at a glance.Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology.Cerebral cavernous malformations: from molecular pathogenesis to genetic counselling and clinical management.Mitochondrial Ca(2+) and apoptosis.Genetic and cellular basis of cerebral cavernous malformations: implications for clinical management.CCM1 and the second life of proteins in adhesion complexes.Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.Beyond multiple mechanisms and a unique drug: Defective autophagy as pivotal player in cerebral cavernous malformation pathogenesis and implications for targeted therapies.KRIT1 loss of function causes a ROS-dependent upregulation of c-JunEvaluation of the bioactive properties of avenanthramide analogs produced in recombinant yeast.Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin.Genome-Wide Sequencing Reveals MicroRNAs Downregulated in Cerebral Cavernous Malformations.miR-21 coordinates tumor growth and modulates KRIT1 levels.Molecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk?Investigation of the neuroprotective effects of a novel synthetic compound via the mitochondrial pathway.Decreased Krev interaction-trapped 1 expression leads to increased vascular permeability and modifies inflammatory responses in vivo.Platinum nanozymes recover cellular ROS homeostasis in an oxidative stress-mediated disease model.KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease.Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles.Nuclear Localization of Integrin Cytoplasmic Domain-associated Protein-1 (ICAP1) Influences β1 Integrin Activation and Recruits Krev/Interaction Trapped-1 (KRIT1) to the Nucleus.Data in support of sustained upregulation of adaptive redox homeostasis mechanisms caused by KRIT1 loss-of-function.Biological Activities, Health Benefits, and Therapeutic Properties of Avenanthramides: From Skin Protection to Prevention and Treatment of Cerebrovascular Diseases
P2860
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P2860
KRIT1 regulates the homeostasis of intracellular reactive oxygen species
description
2010 nî lūn-bûn
@nan
2010 թուականին հրատարակուած գիտական յօդուած
@hyw
2010 թվականին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
KRIT1 regulates the homeostasis of intracellular reactive oxygen species
@ast
KRIT1 regulates the homeostasis of intracellular reactive oxygen species
@en
KRIT1 regulates the homeostasis of intracellular reactive oxygen species
@en-gb
KRIT1 regulates the homeostasis of intracellular reactive oxygen species
@nl
type
label
KRIT1 regulates the homeostasis of intracellular reactive oxygen species
@ast
KRIT1 regulates the homeostasis of intracellular reactive oxygen species
@en
KRIT1 regulates the homeostasis of intracellular reactive oxygen species
@en-gb
KRIT1 regulates the homeostasis of intracellular reactive oxygen species
@nl
prefLabel
KRIT1 regulates the homeostasis of intracellular reactive oxygen species
@ast
KRIT1 regulates the homeostasis of intracellular reactive oxygen species
@en
KRIT1 regulates the homeostasis of intracellular reactive oxygen species
@en-gb
KRIT1 regulates the homeostasis of intracellular reactive oxygen species
@nl
P2093
P2860
P50
P921
P3181
P1433
P1476
KRIT1 regulates the homeostasis of intracellular reactive oxygen species
@en
P2093
Fiorella Balzac
Luca Goitre
Paolo Degan
Simona Degani
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0011786
P407
P577
2010-01-01T00:00:00Z