T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression
about
A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.Basal immunoglobulin signaling actively maintains developmental stage in immature B cells.Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signallingG6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2c-Cbl-mediated regulation of LAT-nucleated signaling complexesSingle-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells.Systematic analysis of head-to-head gene organization: evolutionary conservation and potential biological relevance.Micromanagement of lymphomas.Impact of the TCR signal on regulatory T cell homeostasis, function, and traffickingNovel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells.Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases.Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expressionT-cell receptor revision: friend or foe?Modulation of TCRβ surface expression during TCR revision.Receptor revision in CD4 T cells is influenced by follicular helper T cell formation and germinal-center interactions.Regulation of activation and recombination of the murine Igkappa locus.A CRISPR-Based Toolbox for Studying T Cell Signal Transduction.T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice.ITAM-mediated tonic signalling through pre-BCR and BCR complexes.Viral immunoreceptor-associated tyrosine-based activation motifs: potential players in oncogenesis.Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cellsActivation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.An essential role for the MAL protein in targeting Lck to the plasma membrane of human T lymphocytesPhorbol ester-mediated re-expression of endogenous LAT adapter in J.CaM2 cells: a model for dissecting drivers and blockers of LAT transcription.The effects of c-Abl mutation on developing B cell differentiation and survivalMechanisms controlling expression of the RAG locus during lymphocyte development.Abl tyrosine kinases in T-cell signalingBasal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells.Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies.Recent insights into the transcriptional control of the Tcra/Tcrd locus by distant enhancers during the development of T-lymphocytes.Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.The B cell inhibitory Fc receptor triggers apoptosis by a novel c-Abl family kinase-dependent pathway.A Novel Quantitative Fluorescent Reporter Assay for RAG Targets and RAG Activity.ArtinM Mediates Murine T Cell Activation and Induces Cell Death in Jurkat Human Leukemic T Cells.Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signalingCellular ITAM-containing proteins are oncoproteins in nonhematopoietic cells.Gene expression profiling of hybridoma cells after bursal-derived bioactive factor BP5 treatment.
P2860
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P2860
T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression
description
2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
T cell receptor-independent ba ...... suppresses RAG gene expression
@ast
T cell receptor-independent ba ...... suppresses RAG gene expression
@en
T cell receptor-independent ba ...... suppresses RAG gene expression
@en-gb
T cell receptor-independent ba ...... suppresses RAG gene expression
@nl
type
label
T cell receptor-independent ba ...... suppresses RAG gene expression
@ast
T cell receptor-independent ba ...... suppresses RAG gene expression
@en
T cell receptor-independent ba ...... suppresses RAG gene expression
@en-gb
T cell receptor-independent ba ...... suppresses RAG gene expression
@nl
altLabel
T Cell Receptor-Independent Ba ...... Suppresses RAG Gene Expression
@en
prefLabel
T cell receptor-independent ba ...... suppresses RAG gene expression
@ast
T cell receptor-independent ba ...... suppresses RAG gene expression
@en
T cell receptor-independent ba ...... suppresses RAG gene expression
@en-gb
T cell receptor-independent ba ...... suppresses RAG gene expression
@nl
P2093
P2860
P50
P3181
P1433
P1476
T cell receptor-independent ba ...... suppresses RAG gene expression
@en
P2093
Ash A Alizadeh
Jeroen P Roose
Joseph Lin
P2860
P3181
P356
10.1371/JOURNAL.PBIO.0000053
P407
P577
2003-11-01T00:00:00Z