about
P688
EPS8, encoding an actin-binding protein of cochlear hair cell stereocilia, is a new causal gene for autosomal recessive profound deafness.IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasivenessIsolation and characterization of e3B1, an eps8 binding protein that regulates cell growthStructure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathioneAn effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machineMolecular basis for the dual function of Eps8 on actin dynamics: bundling and cappingEps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF)Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complexThe insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticityIncreased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamicsSCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progressionThe signaling adaptor Eps8 is an essential actin capping protein for dendritic cell migrationEps8 controls actin-based motility by capping the barbed ends of actin filamentsProgressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.Conditional deletion of Eps8 reduces hippocampal synaptic plasticity and impairs cognitive function.
P921
Q21202842-A8425038-F52D-4381-B952-1319120C854EQ24300415-5B5F5BC6-0013-4D77-9D97-726ED803E0DEQ24315841-8849B016-07CE-47E9-9BE7-9868ADE1D28AQ24338497-E99FD363-55B4-4154-B8D4-5A9612CEBAA8Q24670117-CBDDA66B-63AA-4489-960D-3A1E5A80EDB0Q27324384-9171B21C-16E8-45E8-B400-F4EE779BA305Q27330089-675A4A2D-9BE5-4673-A5FA-DCC456DF0EDEQ28504869-7FD19949-7548-444F-A208-B1FE9C757CA4Q28505970-16133D2C-5B4C-4348-B92D-55EC4BCA8CCAQ28509086-32CA3547-3C69-482B-8E67-30F9D6AC0953Q28585492-72F3A47A-76DA-467F-B45A-A0CA50318F17Q28588762-46194FE9-3465-4ECA-9700-80F0A6017C21Q28589982-D1B60A9F-1B90-4155-8AD4-A3AC6167B57CQ28593794-13F3D388-3799-4EEA-8A62-E997E332C10EQ30543591-5105FCB3-08B6-4879-961E-3DF265A7F211Q42496711-D14C93CC-E519-43A2-A7B8-1E3894E04D1A
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
proteinë
@sq
proteïne in Epidermal growth factor receptor pathway substrate 8
@nl
protèin
@ace
بروتين في فأر المنازل
@ar
name
Epidermal growth factor receptor pathway substrate 8
@en
type
label
Epidermal growth factor receptor pathway substrate 8
@en
altLabel
Eps8
@en
epidermal growth factor receptor kinase substrate 8
@en
prefLabel
Epidermal growth factor receptor pathway substrate 8
@en
P361
P527
P637
P638
P680
P681
P682
P705
P352
P637
P31
P352
P361
P527
P637
NP_001258516
NP_001258517
NP_001258518
NP_001258524
XP_006505571
XP_011239506
XP_017176872
XP_030111005
P638
P680
P681
P682
P702
P703
P705
ENSMUSP00000052776
ENSMUSP00000098402
ENSMUSP00000107509
ENSMUSP00000119997
ENSMUSP00000120044
ENSMUSP00000120648
ENSMUSP00000122517
ENSMUSP00000145059