Sortilin-related receptor, LDLR class A repeats-containing
about
P688
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzymeRetromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulationInteraction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's diseaseLoss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's diseaseSortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesisSorting protein-related receptor SorLA controls regulated secretion of glial cell line-derived neurotrophic factor.Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans.SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesityEctodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand head activator.Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein.
P921
Q24300851-B1BA5695-7982-4E04-8203-449D621DF407Q24654821-9F682CE7-1E71-4ED1-A3C8-1FBA47094D89Q28509728-80399FA8-1A01-474E-A726-E0DDECAD7102Q28585628-0543405B-A9DC-4EA5-8C47-D27221D0D5DDQ28588884-1E6CF6B6-2CBA-421B-AAF3-604D146F5459Q28593810-9E475647-8BFC-462C-83DB-D3E036FFAFACQ35842258-C23D6DB3-AA6C-4D22-B62B-FA4D3F44F6F2Q36358239-DD541CAE-9EF8-48F5-B6FF-952801CD584AQ37042293-56AAC809-DC83-4D09-9659-71E2568DA879Q38306595-A08C4FED-CF6F-42EC-B598-B47C4FDE8777Q46637160-19A1FA6A-F544-498C-94D5-94202380D43A
P921
Sortilin-related receptor, LDLR class A repeats-containing
description
mammalian protein found in Mus musculus
@en
protein
@id
proteinë
@sq
proteïne in Sortilin-related receptor, LDLR class A repeats-containing
@nl
protèin
@ace
بروتين في فأر المنازل
@ar
name
Sortilin-related receptor, LDLR class A repeats-containing
@en
Sortilin-related receptor, LDLR class A repeats-containing
@nl
type
label
Sortilin-related receptor, LDLR class A repeats-containing
@en
Sortilin-related receptor, LDLR class A repeats-containing
@nl
altLabel
Gp250
@en
LDLR relative with 11 ligand-binding repeats
@en
LR11
@en
Sorl1
@en
low-density lipoprotein receptor relative with 11 ligand-binding repeats
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mSorLA
@en
sorLA-1
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sortilin-related receptor
@en
sorting protein-related receptor containing LDLR class A repeats
@en
prefLabel
Sortilin-related receptor, LDLR class A repeats-containing
@en
Sortilin-related receptor, LDLR class A repeats-containing
@nl
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ENSMUSP00000058613