Structural basis of Smad2 recognition by the Smad anchor for receptor activation
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The mechanism of nuclear export of Smad3 involves exportin 4 and RanSmad3 allostery links TGF-beta receptor kinase activation to transcriptional controlThe integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokinesAxin facilitates Smad3 activation in the transforming growth factor beta signaling pathwayHereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of diseaseInhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARAPseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase by hnRNP-UErbin inhibits transforming growth factor beta signaling through a novel Smad-interacting domainThe SmadsA Tale from TGF-β Superfamily for Thymus Ontogeny and FunctionTGF-β signaling via TAK1 pathway: role in kidney fibrosisCrystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivationStructural Basis for CD44 Recognition by ERM ProteinsStructure ofDrosophilaMad MH2 domainCrystal structure of the MH2 domain of Drosophila MadMolecular Mechanism of the Negative Regulation of Smad1/5 Protein by Carboxyl Terminus of Hsc70-interacting Protein (CHIP)Interaction domains: from simple binding events to complex cellular behaviorCrossing SmadsRoles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signalingEndofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signalingThe role of internalization in transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cellsDifferent Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif.The FYVE domain of Smad Anchor for Receptor Activation (SARA) is required to prevent skin carcinogenesis, but not in mouse developmentDisorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificityTranscriptional control by the TGF-beta/Smad signaling systemOverview of protein structural and functional folds.RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3.Mechanism for mutational inactivation of the tumor suppressor Smad2.Peptide ligands that use a novel binding site to target both TGF-β receptors.Mutations in protein-binding hot-spots on the hub protein Smad3 differentially affect its protein interactions and Smad3-regulated gene expressionβ-Galactoside α2,6-sialyltranferase 1 promotes transforming growth factor-β-mediated epithelial-mesenchymal transition.Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling.Increased pSmad2 expression and cytoplasmic predominant presence of TGF-βRII in breast cancer tissue are associated with poor prognosis: results from the Shanghai Breast Cancer Study.Structure of the N-terminal domain of the protein Expansion: an 'Expansion' to the Smad MH2 fold.TGF-β signaling and its role in the regulation of hematopoietic stem cells.Involvement of SARA in Axon and Dendrite Growth.aV integrins and TGF-β-induced EMT: a circle of regulationAldose Reductase Mediates Transforming Growth Factor β2 (TGF-β2)-Induced Migration and Epithelial-To-Mesenchymal Transition of Lens-Derived Epithelial Cells.p21-Activated kinase 2 (PAK2) inhibits TGF-β signaling in Madin-Darby canine kidney (MDCK) epithelial cells by interfering with the receptor-Smad interactionSchistosoma mansoni: TGF-beta signaling pathways.
P2860
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P2860
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
description
2000 nî lūn-bûn
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2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
@ast
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
@en
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
@en-gb
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
@nl
type
label
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
@ast
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
@en
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
@en-gb
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
@nl
prefLabel
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
@ast
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
@en
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
@en-gb
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
@nl
P2093
P1433
P1476
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
@en
P2093
C A Gyuricza
J Massagué
P356
10.1126/SCIENCE.287.5450.92
P407
P577
2000-01-07T00:00:00Z