Deterministic mutation rate variation in the human genome
about
Hotspots of biased nucleotide substitutions in human genesComparison of the chicken and turkey genomes reveals a higher rate of nucleotide divergence on microchromosomes than macrochromosomesGenes involved in complex adaptive processes tend to have highly conserved upstream regions in mammalian genomes.Variable Autosomal and X Divergence Near and Far from Genes Affects Estimates of Male Mutation Bias in Great ApesThe mutation spectrum in genomic late replication domains shapes mammalian GC contentAnalysis of transitions at two-fold redundant sites in mammalian genomes. Transition redundant approach-to-equilibrium (TREx) distance metrics.Genomic divergences among cattle, dog and human estimated from large-scale alignments of genomic sequencesThe scale of mutational variation in the murid genomeAdaptive evolution of conserved noncoding elements in mammals.Spontaneous Mutation Rate in the Smallest Photosynthetic EukaryotesThe heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L regionA new framework for studying the isochore evolution: estimation of the equilibrium GC content based on the temporal mutation rate modelReduced variation on the chicken Z chromosome.The embedding problem for markov models of nucleotide substitution.Analysis of primate genomic variation reveals a repeat-driven expansion of the human genome.Neutral substitutions occur at a faster rate in exons than in noncoding DNA in primate genomesCovariation in frequencies of substitution, deletion, transposition, and recombination during eutherian evolutionExploiting CpG hypermutability to identify phenotypically significant variation within human protein-coding genesSubstitution rate variation at human CpG sites correlates with non-CpG divergence, methylation level and GC content.What are the determinants of gene expression levels and breadths in the human genome?Determining the Effect of Natural Selection on Linked Neutral Divergence across SpeciesDistinct contributions of replication and transcription to mutation rate variation of human genomes.Patterns of insertions and their covariation with substitutions in the rat, mouse, and human genomes.Understanding what determines the frequency and pattern of human germline mutations.The influence of genomic context on mutation patterns in the human genome inferred from rare variants.Identification of novel prostate cancer drivers using RegNetDriver: a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network.Conservation of neutral substitution rate and substitutional asymmetries in mammalian genes.Genomic regionality in rates of evolution is not explained by clustering of genes of comparable expression profile.Preferential Protection of Genetic Fidelity within Open Chromatin by the Mismatch Repair MachinerySequence diversity and molecular evolutionary rates between buffalo and cattle.Reverse polarization in amino acid and nucleotide substitution patterns between human-mouse orthologs of two compositional extrema.Evolutionary constraints in conserved nongenic sequences of mammals.Comparative analysis of context-dependent mutagenesis using human and mouse modelsA neutral explanation for the correlation of diversity with recombination rates in humans.The rate, not the spectrum, of base pair substitutions changes at a GC-content transition in the human NF1 gene region: implications for the evolution of the mammalian genome structure.Late-replicating domains have higher divergence and diversity in Drosophila melanogaster.Phen-Gen: combining phenotype and genotype to analyze rare disorders.Unprecedented heterogeneity in the synonymous substitution rate within a plant genome.Sequence diversity and rates of molecular evolution between sheep and cattle genes.Characteristics, causes and evolutionary consequences of male-biased mutation.
P2860
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P2860
Deterministic mutation rate variation in the human genome
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Deterministic mutation rate variation in the human genome
@ast
Deterministic mutation rate variation in the human genome
@en
Deterministic mutation rate variation in the human genome
@en-gb
Deterministic mutation rate variation in the human genome
@nl
type
label
Deterministic mutation rate variation in the human genome
@ast
Deterministic mutation rate variation in the human genome
@en
Deterministic mutation rate variation in the human genome
@en-gb
Deterministic mutation rate variation in the human genome
@nl
prefLabel
Deterministic mutation rate variation in the human genome
@ast
Deterministic mutation rate variation in the human genome
@en
Deterministic mutation rate variation in the human genome
@en-gb
Deterministic mutation rate variation in the human genome
@nl
P2860
P3181
P356
P1433
P1476
Deterministic mutation rate variation in the human genome
@en
P2093
Nick G C Smith
P2860
P304
P3181
P356
10.1101/GR.220502
P407
P577
2002-09-01T00:00:00Z