Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress
about
Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stressDimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stressGrowth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERKNck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translationEvidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulinRegulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.Regulation of Stress Responses and Translational Control by CoronavirusProtein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytesThe structure of the PERK kinase domain suggests the mechanism for its activationPERK mediates cell-cycle exit during the mammalian unfolded protein responseBiochemical analysis of the eIF2beta gamma complex reveals a structural function for eIF2alpha in catalyzed nucleotide exchangeDifferential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylationThe PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreasActivating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress responseFeedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alphaResistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKRPERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathwayDown-Regulatory Effects of miR-211 on Long Non-Coding RNA SOX2OT and SOX2 Genes in Esophageal Squamous Cell Carcinoma.Arctigenin alleviates ER stress via activating AMPK.Herpes simplex virus 1 infection activates the endoplasmic reticulum resident kinase PERK and mediates eIF-2alpha dephosphorylation by the gamma(1)34.5 protein.PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alphaStressed to death: targeting endoplasmic reticulum stress response induced apoptosis in gliomas.Stanniocalcin 2 alters PERK signalling and reduces cellular injury during cerulein induced pancreatitis in mice.Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase.Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response.P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling.Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes.The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.Gene expression profiling of the long-term adaptive response to hypoxia in the gills of adult zebrafish.Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses.Viruses, endoplasmic reticulum stress, and interferon responses.Differential activation of eIF2 kinases in response to cellular stresses in Schizosaccharomyces pombe.RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway.Conserved intermolecular salt bridge required for activation of protein kinases PKR, GCN2, and PERK.Translation initiation and its deregulation during tumorigenesisRegulation of sumo mRNA during endoplasmic reticulum stress.Resistance of mRNA translation to acute endoplasmic reticulum stress-inducing agents in herpes simplex virus type 1-infected cells requires multiple virus-encoded functions.Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses.Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides
P2860
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P2860
Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress
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2000 nî lūn-bûn
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2000年の論文
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Pancreatic eukaryotic initiati ...... o endoplasmic reticulum stress
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Pancreatic eukaryotic initiati ...... o endoplasmic reticulum stress
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Pancreatic eukaryotic initiati ...... o endoplasmic reticulum stress
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Pancreatic eukaryotic initiati ...... o endoplasmic reticulum stress
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Pancreatic eukaryotic initiati ...... o endoplasmic reticulum stress
@ast
Pancreatic eukaryotic initiati ...... o endoplasmic reticulum stress
@en
Pancreatic eukaryotic initiati ...... o endoplasmic reticulum stress
@en-gb
Pancreatic eukaryotic initiati ...... o endoplasmic reticulum stress
@nl
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Pancreatic eukaryotic initiati ...... o endoplasmic reticulum stress
@ast
Pancreatic eukaryotic initiati ...... o endoplasmic reticulum stress
@en
Pancreatic eukaryotic initiati ...... o endoplasmic reticulum stress
@en-gb
Pancreatic eukaryotic initiati ...... o endoplasmic reticulum stress
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P2093
P2860
P921
P3181
P1433
P1476
Pancreatic eukaryotic initiati ...... o endoplasmic reticulum stress
@en
P2093
P2860
P304
P3181
P356
10.1042/0264-6021:3460281
10.1042/BJ3460281
P407
P478
P577
2000-03-01T00:00:00Z