Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis
about
The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductasesRegulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunitMechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase.Class II 3-hydroxy-3-methylglutaryl coenzyme A reductasesCommon SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13Dual functions of Insig proteins in cholesterol homeostasisCrystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductaseStructures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transductionGenetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae.Membrane topology of human insig-1, a protein regulator of lipid synthesisExploration of virtual candidates for human HMG-CoA reductase inhibitors using pharmacophore modeling and molecular dynamics simulationsChemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasisGlucose-6-phosphate dehydrogenase and NADPH redox regulates cardiac myocyte L-type calcium channel activity and myocardial contractile functionEffects of hypocholesterolaemic agents on the expression and activity of 3-hydroxy-3-methylglutaryl-CoA reductase in the fat body of the German cockroach.Regulation of ipsilateral and contralateral bovine oviduct epithelial cell function in the postovulation period: a transcriptomics approach.Enterococcus faecalis phosphomevalonate kinase.Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statinsAn Insight Into Structure, Function, and Expression Analysis of 3-Hydroxy-3-Methylglutaryl-CoA Reductase of Cymbopogon winterianus.Enhancing MAD F(A) data for substructure determination.In vitro screening for β-hydroxy-β-methylglutaryl-CoA reductase inhibitory and antioxidant activity of sequentially extracted fractions of Ficus palmata Forsk.Transcription of the three HMG-CoA reductase genes of Mucor circinelloidesA mathematical model of the sterol regulatory element binding protein 2 cholesterol biosynthesis pathway.Essentiality, expression, and characterization of the class II 3-hydroxy-3-methylglutaryl coenzyme A reductase of Staphylococcus aureus.Anomalous diffraction in crystallographic phase evaluationEnzymes of the mevalonate pathway of isoprenoid biosynthesisEnterococcus faecalis acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase, a dual-function protein of isopentenyl diphosphate biosynthesis.Enterococcus faecalis 3-hydroxy-3-methylglutaryl coenzyme A synthase, an enzyme of isopentenyl diphosphate biosynthesis.A novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) splice variant with an alternative exon 1 potentially encoding an extended N-terminus.Sequence diversity in genes of lipid metabolismThe inhibitory effects of bioactive compounds of tomato juice binding to hepatic HMGCR: in vivo study and molecular modelling.Regulation of HMG-CoA reductase in mammals and yeastThyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver.Isoprenoid biosynthesis is required for miRNA function and affects membrane association of ARGONAUTE 1 in Arabidopsis.Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism.Insight into the mechanism of polyphenols on the activity of HMGR by molecular docking.A comparative analysis of protein targets of withdrawn cardiovascular drugs in human and mouseMolecular modeling of the reaction pathway and hydride transfer reactions of HMG-CoA reductase.Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatinRole of rs3846662 and HMGCR alternative splicing in statin efficacy and baseline lipid levels in familial hypercholesterolemia.Effects of rs3846662 Variants on HMGCR mRNA and Protein Levels and on Markers of Alzheimer's Disease Pathology.
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P2860
Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis
description
2000 nî lūn-bûn
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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name
Crystal structure of the catal ...... tion of activity and catalysis
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Crystal structure of the catal ...... tion of activity and catalysis
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Crystal structure of the catal ...... tion of activity and catalysis
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Crystal structure of the catal ...... tion of activity and catalysis
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Crystal structure of the catal ...... tion of activity and catalysis
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Crystal structure of the catal ...... tion of activity and catalysis
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Crystal structure of the catal ...... tion of activity and catalysis
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Crystal structure of the catal ...... tion of activity and catalysis
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Crystal structure of the catal ...... tion of activity and catalysis
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Crystal structure of the catal ...... tion of activity and catalysis
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Crystal structure of the catal ...... tion of activity and catalysis
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Crystal structure of the catal ...... tion of activity and catalysis
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P2093
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Crystal structure of the catal ...... tion of activity and catalysis
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P2093
E S Istvan
M Palnitkar
S K Buchanan
P2860
P304
P356
10.1093/EMBOJ/19.5.819
P407
P577
2000-03-01T00:00:00Z