Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate
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Pathogenic mechanisms in centronuclear myopathiesMyotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth diseaseRegulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphataseMalin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG)Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin.The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth diseaseIdentification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAPCharacterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9Myotubularin controls desmin intermediate filament architecture and mitochondrial dynamics in human and mouse skeletal muscle.The myotubularin-amphiphysin 2 complex in membrane tubulation and centronuclear myopathiesRegulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteinsMolecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase.Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretionThe Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnoverIdentification of mitogen-activated protein kinase docking sites in enzymes that metabolize phosphatidylinositols and inositol phosphates.Phosphoinositides: tiny lipids with giant impact on cell regulationMetabolism and regulation of glycerolipids in the yeast Saccharomyces cerevisiaeLoss of myotubularin function results in T-tubule disorganization in zebrafish and human myotubular myopathyMTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegansLoss of catalytically inactive lipid phosphatase myotubularin-related protein 12 impairs myotubularin stability and promotes centronuclear myopathy in zebrafishGenetic Screen in Drosophila Larvae Links ird1 Function to Toll Signaling in the Fat Body and Hemocyte MotilityPhosphoinositide regulation of integrin trafficking required for muscle attachment and maintenanceCaenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cellsStructural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesisStructural basis for substrate recognition by a unique Legionella phosphoinositide phosphataseEssential role for the myotubularin-related phosphatase Ymr1p and the synaptojanin-like phosphatases Sjl2p and Sjl3p in regulation of phosphatidylinositol 3-phosphate in yeast.Membrane topology and essential amino acid residues of Phs1, a 3-hydroxyacyl-CoA dehydratase involved in very long-chain fatty acid elongation.Multimerization of the protein-tyrosine phosphatase (PTP)-like insulin-dependent diabetes mellitus autoantigens IA-2 and IA-2beta with receptor PTPs (RPTPs). Inhibition of RPTPalpha enzymatic activityGenetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathiesMechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis.A PTEN-like phosphatase with a novel substrate specificityThe lipid phosphatase myotubularin is essential for skeletal muscle maintenance but not for myogenesis in miceConservation of the glucan phosphatase laforin is linked to rates of molecular evolution and the glucan metabolism of the organismArchaeal protein kinases and protein phosphatases: insights from genomics and biochemistryA unique carbohydrate binding domain targets the lafora disease phosphatase to glycogen.Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo.Compartmental signal modulation: Endosomal phosphatidylinositol 3-phosphate controls endosome morphology and selective cargo sorting.Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy
P2860
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P2860
Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate
description
2000 nî lūn-bûn
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2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2000 թվականի օգոստոսին հրատարակված գիտական հոդված
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name
Myotubularin, a protein tyrosi ...... osphatidylinositol 3-phosphate
@ast
Myotubularin, a protein tyrosi ...... osphatidylinositol 3-phosphate
@en
Myotubularin, a protein tyrosi ...... osphatidylinositol 3-phosphate
@en-gb
Myotubularin, a protein tyrosi ...... osphatidylinositol 3-phosphate
@nl
type
label
Myotubularin, a protein tyrosi ...... osphatidylinositol 3-phosphate
@ast
Myotubularin, a protein tyrosi ...... osphatidylinositol 3-phosphate
@en
Myotubularin, a protein tyrosi ...... osphatidylinositol 3-phosphate
@en-gb
Myotubularin, a protein tyrosi ...... osphatidylinositol 3-phosphate
@nl
prefLabel
Myotubularin, a protein tyrosi ...... osphatidylinositol 3-phosphate
@ast
Myotubularin, a protein tyrosi ...... osphatidylinositol 3-phosphate
@en
Myotubularin, a protein tyrosi ...... osphatidylinositol 3-phosphate
@en-gb
Myotubularin, a protein tyrosi ...... osphatidylinositol 3-phosphate
@nl
P2093
P2860
P921
P3181
P356
P1476
Myotubularin, a protein tyrosi ...... osphatidylinositol 3-phosphate
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.160255697
P407
P577
2000-08-01T00:00:00Z