Asef, a link between the tumor suppressor APC and G-protein signaling
about
RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activationIdentification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cellsNm23-H1 modulates the activity of the guanine exchange factor Dbl-1Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEFTrabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chainsThe adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)miceThe tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesisHuman scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coliAsef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migrationAsef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation elementLack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stabilityTo build a synapse: signaling pathways in neuromuscular junction assemblyRole of APC and DNA mismatch repair genes in the development of colorectal cancers.Global gene expression profiling of cells overexpressing SMC3.Examination of actin and microtubule dependent APC localisations in living mammalian cells.Regulation of small GTPases by GEFs, GAPs, and GDIsEB1 is required for spindle symmetry in mammalian mitosisAutomated screening of microtubule growth dynamics identifies MARK2 as a regulator of leading edge microtubules downstream of Rac1 in migrating cellsTubulin tyrosination is required for the proper organization and pathfinding of the growth coneCrystal structure of the rac activator, Asef, reveals its autoinhibitory mechanismRelease of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppressionStructure of the Human Discs Large 1 PDZ2– Adenomatous Polyposis Coli Cytoskeletal Polarity Complex: Insight into Peptide Engagement and PDZ ClusteringA conformational switch in collybistin determines the differentiation of inhibitory postsynapsesRas superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesisThe β-catenin destruction complexIQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis colidifferent Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coliApoptosis in neural crest cells by functional loss of APC tumor suppressor geneAdenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.Conserved microtubule-actin interactions in cell movement and morphogenesisRHO-GTPases and cancerStructural basis for the recognition of Asef by adenomatous polyposis coli.Autoinhibition of GEF activity in Intersectin 1 is mediated by the short SH3-DH domain linker.Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts.Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites.Molecular features of adult mouse small intestinal epithelial progenitorsColorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers.Novel association of APC with intermediate filaments identified using a new versatile APC antibody
P2860
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P2860
Asef, a link between the tumor suppressor APC and G-protein signaling
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2000 nî lūn-bûn
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2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2000 թվականի օգոստոսին հրատարակված գիտական հոդված
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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Asef, a link between the tumor suppressor APC and G-protein signaling
@ast
Asef, a link between the tumor suppressor APC and G-protein signaling
@en
Asef, a link between the tumor suppressor APC and G-protein signaling
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Asef, a link between the tumor suppressor APC and G-protein signaling
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Asef, a link between the tumor suppressor APC and G-protein signaling
@ast
Asef, a link between the tumor suppressor APC and G-protein signaling
@en
Asef, a link between the tumor suppressor APC and G-protein signaling
@en-gb
Asef, a link between the tumor suppressor APC and G-protein signaling
@nl
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Asef, a link between the tumor suppressor APC and G-protein signaling
@ast
Asef, a link between the tumor suppressor APC and G-protein signaling
@en
Asef, a link between the tumor suppressor APC and G-protein signaling
@en-gb
Asef, a link between the tumor suppressor APC and G-protein signaling
@nl
P2093
P3181
P1433
P1476
Asef, a link between the tumor suppressor APC and G-protein signaling
@en
P2093
T Ishidate
T Morishita
Y Kawasaki
P304
P3181
P356
10.1126/SCIENCE.289.5482.1194
P407
P577
2000-08-18T00:00:00Z