Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
about
Glycogen synthesis correlates with androgen-dependent growth arrest in prostate cancer.Molecular recognition of the protein phosphatase 1 glycogen targeting subunit by glycogen phosphorylaseGlycogen metabolism has a key role in the cancer microenvironment and provides new targets for cancer therapyDiscovery of an allosteric site in the caspasesGlycogen phosphorylase inhibitors for treatment of type 2 diabetes mellitus.Structure-based predictive models for allosteric hot spots.Hit clustering can improve virtual fragment screening: CDK2 and PARP1 case studies.Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharidesKinetic and crystallographic studies on 2-(beta-D-glucopyranosyl)-5-methyl-1, 3, 4-oxadiazole, -benzothiazole, and -benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site.Multivalent inhibitors for carbohydrate-processing enzymes: beyond the "lock-and-key" concept.Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase.Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Glycogen phosphorylase inhibition improves beta cell function.Targeting hepatic glucose metabolism in the treatment of type 2 diabetes.Endogenous effectors of human liver glycogen phosphorylase modulate effects of indole-site inhibitors.Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation state of the enzyme.The effect of glucose on the potency of two distinct glycogen phosphorylase inhibitors.An assessment of the in vivo efficacy of the glycogen phosphorylase inhibitor GPi688 in rat models of hyperglycaemia.Diverse effects of two allosteric inhibitors on the phosphorylation state of glycogen phosphorylase in hepatocytes.Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysis.Integrated effects of multiple modulators on human liver glycogen phosphorylase a.Cardioprotective effects of ingliforib, a novel glycogen phosphorylase inhibitor.Crystal structures of eukaryote glycosyltransferases reveal biologically relevant enzyme homooligomers.
P2860
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P2860
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
description
2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年學術文章
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Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
@ast
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
@en
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
@en-gb
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
@nl
type
label
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
@ast
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
@en
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
@en-gb
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
@nl
prefLabel
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
@ast
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
@en
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
@en-gb
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
@nl
P2093
P921
P1476
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
@en
P2093
A M Mathiowetz
D E Danley
D J Hoover
J L Ekstrom
J L Treadway
M Ammirati
R K McPherson
P304
P356
10.1016/S1074-5521(00)00004-1
P407
P577
2000-09-01T00:00:00Z