Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
about
The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complexHuman CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complexMammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and NotchAlzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formationAn alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitorTransmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complexCD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide productionSyntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide productionPresenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formationNicalin and its binding partner Nomo are novel Nodal signaling antagonistsPathways towards and away from Alzheimer's diseaseThe gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sampleCurcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st centuryThe neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer diseaseWhen loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer diseaseThe presenilinsSynaptic function of nicastrin in hippocampal neuronsConditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegenerationStepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugsDiabetes Mellitus Induces Alzheimer's Disease Pathology: Histopathological Evidence from Animal ModelsGolgi fragmentation in Alzheimer's diseaseCaenorhabditis elegans as a model organism to study APP functionInsights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's diseaseToward the structure of presenilin/γ-secretase and presenilin homologsGeneral anesthetics and β-amyloid proteinStructural biology of presenilin 1 complexesStructure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALLComplex regulation of γ-secretase: from obligatory to modulatory subunitsCurrent and future implications of basic and translational research on amyloid-β peptide production and removal pathwaysAn atomic structure of human γ-secretaseThe Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragmentsA conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complexGSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptidesEndoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-proteinThe luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the GolgiCoordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivationProteolytic processing of Alzheimer's β-amyloid precursor proteinPresenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activityBACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's diseaseTime-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues
P2860
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P2860
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
description
2000 nî lūn-bûn
@nan
2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
name
Nicastrin modulates presenilin ...... duction and betaAPP processing
@ast
Nicastrin modulates presenilin ...... duction and betaAPP processing
@en
Nicastrin modulates presenilin ...... duction and betaAPP processing
@en-gb
Nicastrin modulates presenilin ...... duction and betaAPP processing
@nl
type
label
Nicastrin modulates presenilin ...... duction and betaAPP processing
@ast
Nicastrin modulates presenilin ...... duction and betaAPP processing
@en
Nicastrin modulates presenilin ...... duction and betaAPP processing
@en-gb
Nicastrin modulates presenilin ...... duction and betaAPP processing
@nl
prefLabel
Nicastrin modulates presenilin ...... duction and betaAPP processing
@ast
Nicastrin modulates presenilin ...... duction and betaAPP processing
@en
Nicastrin modulates presenilin ...... duction and betaAPP processing
@en-gb
Nicastrin modulates presenilin ...... duction and betaAPP processing
@nl
P2093
P50
P3181
P356
P1433
P1476
Nicastrin modulates presenilin ...... duction and betaAPP processing
@en
P2093
Aebersold R
Levesque L
P2888
P3181
P356
10.1038/35024009
P407
P577
2000-09-01T00:00:00Z
P5875
P6179
1028278722