Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
about
Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatinA repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cellsIdas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progressionThe regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cellsA WD-repeat protein stabilizes ORC binding to chromatinTwo E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.Human Mcm proteins at a replication origin during the G1 to S phase transitionDTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpointCdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin bindingGeminin regulates neuronal differentiation by antagonizing Brg1 activityPSF1 is essential for early embryogenesis in miceMaking sense of eukaryotic DNA replication origins.Regulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidizationThe chromosome cycle: coordinating replication and segregation. Second in the cycles review series.Regulation of replication licensing by acetyltransferase Hbo1.Human cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellular DNA replication.Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycleA requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replicationHuman geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosisRereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpointGeminin promotes neural fate acquisition of embryonic stem cells by maintaining chromatin in an accessible and hyperacetylated statePrevention of DNA re-replication in eukaryotic cellsThe replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplicationReplication licensing and cancer--a fatal entanglement?Preventing re-replication of chromosomal DNA.Endoreplication: polyploidy with purposeThe anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cyclesLoss of Geminin induces rereplication in the presence of functional p53The Croonian Lecture 2001 hunting the antisocial cancer cell: MCM proteins and their exploitationDrosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensationOptimisation of the two-dimensional gel electrophoresis protocol using the Taguchi approachFunctional domains of the Xenopus replication licensing factor Cdt1Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteinsA Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replicationLicensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extractsThe Non-Canonical Role of Aurora-A in DNA ReplicationMechanisms for initiating cellular DNA replicationLoading and activation of DNA replicative helicases: the key step of initiation of DNA replicationGenomic instability in cancer.Replication proteins and human disease
P2860
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P248
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P2860
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
description
2000 nî lūn-bûn
@nan
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
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name
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
@ast
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
@en
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
@en-gb
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
@nl
type
label
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
@ast
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
@en
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
@en-gb
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
@nl
prefLabel
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
@ast
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
@en
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
@en-gb
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
@nl
P2093
P921
P3181
P1433
P1476
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
@en
P2093
P304
P3181
P356
10.1126/SCIENCE.290.5500.2309
P407
P577
2000-12-22T00:00:00Z