Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha
about
Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 bindingCo-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasionThe yeast par-1 homologs kin1 and kin2 show genetic and physical interactions with components of the exocytic machineryParallel coiled-coil association of the RhoA-binding domain in Rho-kinaseStructure of dystrophia myotonica protein kinaseCdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasionThe structure of dimeric ROCK I reveals the mechanism for ligand selectivityHomodimerization through coiled-coil regions enhances activity of the myotonic dystrophy protein kinasePDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction.Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.New insights into the structure-function relationships of Rho-associated kinase: a thermodynamic and hydrodynamic study of the dimer-to-monomer transition and its kinetic implications.Structure basis and unconventional lipid membrane binding properties of the PH-C1 tandem of rho kinasesAlternative splicing controls myotonic dystrophy protein kinase structure, enzymatic activity, and subcellular localization.Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics.Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta.The cytoskeletal regulator Genghis khan is required for columnar target specificity in the Drosophila visual system.Protein kinase C and beyond.PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulationRho kinase, a promising drug target for neurological disorders.Myotonic dystrophy kinase-related Cdc42-binding kinases (MRCK), the ROCK-like effectors of Cdc42 and Rac1.Wealth of opportunity - the C1 domain as a target for drug development.Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization.The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer.Targeting Rho GTPase signaling for cancer therapy.Characterization of RhoA-binding kinase ROKalpha implication of the pleckstrin homology domain in ROKalpha function using region-specific antibodies.Regulatory roles of conserved phosphorylation sites in the activation T-loop of the MAP kinase ERK1Modes of invasion during tumour dissemination.Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCNOvercoming amino-Nogo-induced inhibition of cell spreading and neurite outgrowth by 12-O-tetradecanoylphorbol-13-acetate-type tumor promoters.Activating ROCK1 somatic mutations in human cancer.MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion.
P2860
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P2860
Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
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2001年学术文章
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2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
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name
Intermolecular and intramolecu ...... ted Cdc42-binding kinase alpha
@ast
Intermolecular and intramolecu ...... ted Cdc42-binding kinase alpha
@en
Intermolecular and intramolecu ...... ted Cdc42-binding kinase alpha
@en-gb
Intermolecular and intramolecu ...... ted Cdc42-binding kinase alpha
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type
label
Intermolecular and intramolecu ...... ted Cdc42-binding kinase alpha
@ast
Intermolecular and intramolecu ...... ted Cdc42-binding kinase alpha
@en
Intermolecular and intramolecu ...... ted Cdc42-binding kinase alpha
@en-gb
Intermolecular and intramolecu ...... ted Cdc42-binding kinase alpha
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prefLabel
Intermolecular and intramolecu ...... ted Cdc42-binding kinase alpha
@ast
Intermolecular and intramolecu ...... ted Cdc42-binding kinase alpha
@en
Intermolecular and intramolecu ...... ted Cdc42-binding kinase alpha
@en-gb
Intermolecular and intramolecu ...... ted Cdc42-binding kinase alpha
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P2860
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Intermolecular and intramolecu ...... ted Cdc42-binding kinase alpha
@en
P2093
P2860
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P356
10.1128/MCB.21.8.2767-2778.2001
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P577
2001-04-01T00:00:00Z